Seroatlas · Human Serome Atlas

APOL3

Apolipoprotein L3

Also known as: APOL3_HUMAN, APOLIII, CG12-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95236
Gene
APOL3
Ensembl
ENSG00000128284
Chromosome
22
Canonical length
402 aa
Protein class
Predicted intracellular proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>O95236|APOL3
     1  MGLGQGWGWE ASCFACLIRS CCQVVTFTFP FGFQGISQSL ENVSGYYADA RLEVGSTQLR
    61  TAGSCSHSFK RSFLEKKRFT EEATKYFRER VSPVHLQILL TNNEAWKRFV TAAELPRDEA
   121  DALYEALKKL RTYAAIEDEY VQQKDEQFRE WFLKEFPQVK RKIQESIEKL RALANGIEEV
   181  HRGCTISNVV SSSTGAASGI MSLAGLVLAP FTAGTSLALT AAGVGLGAAS AVTGITTSIV
   241  EHSYTSSAEA EASRLTATSI DRLKVFKEVM RDITPNLLSL LNNYYEATQT IGSEIRAIRQ
   301  ARARARLPVT TWRISAGSGG QAERTIAGTT RAVSRGARIL SATTSGIFLA LDVVNLVYES
   361  KHLHEGAKSA SAEELRRQAQ ELEENLMELT QIYQRLNPCH TH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
92 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 92 nTPM
  • lymph node: 76 nTPM
  • liver: 67 nTPM
  • lung: 60 nTPM
  • adipose tissue: 57 nTPM
  • appendix: 49 nTPM

Single-cell type

  • vascular endothelial cells: 85 nCPM
  • lymphatic endothelial cells: 57 nCPM
  • fibro-adipogenic progenitors: 49 nCPM
  • cdc: 42 nCPM
  • kupffer cells: 42 nCPM
  • fibroblasts: 39 nCPM

Immune cell

  • MAIT T-cell: 56 nTPM
  • intermediate monocyte: 53 nTPM
  • non-classical monocyte: 52 nTPM
  • classical monocyte: 43 nTPM
  • NK-cell: 38 nTPM
  • memory CD8 T-cell: 34 nTPM

Brain region

  • medulla oblongata: 25 nTPM
  • thalamus: 23 nTPM
  • amygdala: 20 nTPM
  • pons: 20 nTPM
  • basal ganglia: 19 nTPM
  • midbrain: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.79
gnomAD pLI
0
gnomAD missense Z
-0.04
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APOL3 as an antibody target. Whether an autoantibody or antibody against APOL3 could matter depends on whether native APOL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APOL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label APOL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/APOL3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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