Seroatlas · Human Serome Atlas

APOL2

Apolipoprotein L2

Also known as: APOL-II, APOL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQE5
Gene: APOL2
Ensembl: ENSG00000128335
Chromosome: 22
Canonical length: 337 aa
Protein class: Cancer-related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>Q9BQE5|APOL2
     1  MNPESSIFIE DYLKYFQDQV SRENLLQLLT DDEAWNGFVA AAELPRDEAD ELRKALNKLA
    61  SHMVMKDKNR HDKDQQHRQW FLKEFPRLKR ELEDHIRKLR ALAEEVEQVH RGTTIANVVS
   121  NSVGTTSGIL TLLGLGLAPF TEGISFVLLD TGMGLGAAAA VAGITCSVVE LVNKLRARAQ
   181  ARNLDQSGTN VAKVMKEFVG GNTPNVLTLV DNWYQVTQGI GRNIRAIRRA RANPQLGAYA
   241  PPPHVIGRIS AEGGEQVERV VEGPAQAMSR GTMIVGAATG GILLLLDVVS LAYESKHLLE
   301  GAKSESAEEL KKRAQELEGK LNFLTKIHEM LQPGQDQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 61 nTPM

Expression across tissuesHPA

Tissue

liver: 61 nTPM
urinary bladder: 56 nTPM
cerebral cortex: 49 nTPM
pituitary gland: 48 nTPM
spleen: 46 nTPM
lung: 44 nTPM

Single-cell type

foveolar cells: 159 nCPM
endometrial luminal cells: 120 nCPM
hepatocytes: 76 nCPM
endometrial glandular cells: 75 nCPM
prostatic hillock cells: 53 nCPM
urothelial cells: 47 nCPM

Immune cell

neutrophil: 116 nTPM
intermediate monocyte: 46 nTPM
gdT-cell: 40 nTPM
MAIT T-cell: 36 nTPM
non-classical monocyte: 34 nTPM
memory CD8 T-cell: 33 nTPM

Brain region

medulla oblongata: 76 nTPM
pons: 76 nTPM
hypothalamus: 57 nTPM
cerebral cortex: 55 nTPM
spinal cord: 55 nTPM
midbrain: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.83
gnomAD pLI: 0.01
gnomAD missense Z: -0.73
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APOL2 as an antibody target. Whether an autoantibody or antibody against APOL2 could matter depends on whether native APOL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APOL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label APOL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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