Seroatlas · Human Serome Atlas

APOF

Apolipoprotein F

Also known as: APOF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13790
Gene: APOF
Ensembl: ENSG00000175336
Chromosome: 12
Canonical length: 326 aa
Protein class: Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>Q13790|APOF
     1  MTGLCGYSAP DMRGLRLIMI PVELLLCYLL LHPVDATSYG KQTNVLMHFP LSLESQTPSS
    61  DPLSCQFLHP KSLPGFSHMA PLPKFLVSLA LRNALEEAGC QADVWALQLQ LYRQGGVNAT
   121  QVLIQHLRGL QKGRSTERNV SVEALASALQ LLAREQQSTG RVGRSLPTED CENEKEQAVH
   181  NVVQLLPGVG TFYNLGTALY YATQNCLGKA RERGRDGAID LGYDLLMTMA GMSGGPMGLA
   241  ISAALKPALR SGVQQLIQYY QDQKDANISQ PETTKEGLRA ISDVSDLEET TTLASFISEV
   301  VSSAPYWGWA IIKSYDLDPG AGSLEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 389 nTPM

Expression across tissuesHPA

Tissue

liver: 389 nTPM
prostate: 1.1 nTPM
retina: 0.3 nTPM
bone marrow: 0.2 nTPM
testis: 0.2 nTPM
appendix: 0.1 nTPM

Single-cell type

hepatocytes: 347 nCPM
kupffer cells: 11 nCPM
cholangiocytes: 6.6 nCPM
prostatic glandular cells: 2.1 nCPM
b-cells: 2 nCPM
cardiomyocytes: 1.6 nCPM

Immune cell

basophil: 0.3 nTPM
naive B-cell: 0.3 nTPM
memory B-cell: 0.2 nTPM
naive CD4 T-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

white matter: 4.1 nTPM
cerebellum: 3.5 nTPM
basal ganglia: 2.7 nTPM
cerebral cortex: 2.7 nTPM
medulla oblongata: 2.7 nTPM
pons: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0.01
gnomAD missense Z: 0.35
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Apolipoprotein F
Apolipoprotein F

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APOF as an antibody target. Whether an autoantibody or antibody against APOF could matter depends on whether native APOF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APOF is annotated as secreted, so native APOF circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label APOF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...