Seroatlas · Human Serome Atlas

APOD

Apolipoprotein D

Also known as: Apo-D, APOD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P05090
Gene
APOD
Ensembl
ENSG00000189058
Chromosome
3
Canonical length
189 aa
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins, Predicted secreted proteins
Subcellular location
Plasma membrane
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>P05090|APOD
     1  MVMLLLLLSA LAGLFGAAEG QAFHLGKCPN PPVQENFDVN KYLGRWYEIE KIPTTFENGR
    61  CIQANYSLME NGKIKVLNQE LRADGTVNQI EGEATPVNLT EPAKLEVKFS WFMPSAPYWI
   121  LATDYENYAL VYSCTCIIQL FHVDFAWILA RNPNLPPETV DSLKNILTSN NIDVKKMTVT
   181  DQVNCPKLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
4,728 nTPM

Expression across tissuesHPA

Tissue

  • breast: 4,728 nTPM
  • choroid plexus: 4,196 nTPM
  • adipose tissue: 2,665 nTPM
  • spinal cord: 1,608 nTPM
  • blood vessel: 1,595 nTPM
  • salivary gland: 1,584 nTPM

Single-cell type

  • decidual stromal cells: 4,996 nCPM
  • fibroblasts: 3,442 nCPM
  • leydig cells: 1,537 nCPM
  • melanocytes: 1,181 nCPM
  • peritubular myoid cells: 1,097 nCPM
  • oligodendrocyte progenitor cells: 457 nCPM

Immune cell

  • memory B-cell: 5 nTPM
  • naive B-cell: 0.3 nTPM
  • non-classical monocyte: 0.3 nTPM
  • basophil: 0.1 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • choroid plexus: 1,385 nTPM
  • white matter: 1,294 nTPM
  • cerebellum: 975 nTPM
  • medulla oblongata: 918 nTPM
  • basal ganglia: 913 nTPM
  • pons: 790 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.34
gnomAD pLI
0
gnomAD missense Z
0.18
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APOD as an antibody target. Whether an autoantibody or antibody against APOD could matter depends on whether native APOD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APOD is annotated as secreted, so native APOD circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label APOD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/APOD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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