APOC1

Protein identityUniProt · HPA

UniProt accession

P02654

Gene

APOC1

Ensembl

ENSG00000130208

Chromosome

19

Canonical length

83 aa

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Metabolic proteins, Plasma proteins, Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

83 residues, UniProt reviewed canonical sequence.

>P02654|APOC1
     1  MRLFLSLPVL VVVLSIVLEG PAPAQGTPDV SSALDKLKEF GNTLEDKARE LISRIKQSEL
    61  SAKMREWFSE TFQKVKEKLK IDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.55

Highest tissue expression

18,660 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about APOC1.

Disease | ImmuneIEDB

Conditions an epitope on APOC1 was assayed in.

• rheumatoid arthritis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.47

gnomAD pLI

0.22

gnomAD missense Z

0.09

DepMap mean gene effect

-0.16

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cholesterol efflux
• cholesterol metabolic process
• chylomicron remnant clearance
• high-density lipoprotein particle remodeling
• lipid metabolic process
• lipoprotein metabolic process
• negative regulation of cholesterol transport
• negative regulation of fatty acid biosynthetic process
• negative regulation of lipid catabolic process
• negative regulation of lipid metabolic process
• negative regulation of receptor-mediated endocytosis
• negative regulation of triglyceride catabolic process
• negative regulation of very-low-density lipoprotein particle clearance
• phospholipid efflux
• plasma lipoprotein particle remodeling
• regulation of cholesterol transport
• triglyceride homeostasis
• triglyceride metabolic process
• very-low-density lipoprotein particle assembly
• very-low-density lipoprotein particle clearance
• negative regulation of phosphatidylcholine catabolic process

Molecular functions

• fatty acid binding
• lipase inhibitor activity
• phosphatidylcholine binding
• phosphatidylcholine-sterol O-acyltransferase activator activity
• phospholipase inhibitor activity

Cellular components

• chylomicron
• endoplasmic reticulum
• extracellular region
• high-density lipoprotein particle
• very-low-density lipoprotein particle

Protein domainsUniProt · Pfam · InterPro

• Apolipoprotein C-I
• Apolipoprotein C-I domain superfamily
• Apolipoprotein C-I (ApoC-1)

KeywordsUniProt

• Lipid transport
• Secreted
• Signal
• Transport
• VLDL