Seroatlas · Human Serome Atlas

APOBR

Apolipoprotein B receptor

Also known as: APOB100R, APOB48R, APOBR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q0VD83
Gene
APOBR
Ensembl
ENSG00000184730
Chromosome
16
Canonical length
1097 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Centrosome
Quaternary structure
Homodimer

OverviewNCBI Gene

Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1097 residues, UniProt reviewed canonical sequence.

>Q0VD83|APOBR
     1  MDFLRLYLPG LHQALRGALD SLGTFVSYLL GDAVPTVERE AQAAEELGVV AVGKTGKIVE
    61  EEAQEDLEGL RGSQNEGAGR LRGPGDDRRH EVGSSAVEQT WGWGDGSSHG SQAERQDSGA
   121  GETAKAARCQ EPSAHLEARK KSKAGSGACQ DRSGQAQERQ ESHEQEVNRE ERLRSWEQEE
   181  EEEEVRAREP GMARGAESEW TWHGETEGKA GAVGPKAAGD NREMEQGVRE ADAGETEEPG
   241  AEGAGKGEEV VVVEKACEST RAWGTWGPGA EPEDWGILGR EEARTTPGRE EARAILDGEE
   301  ARTISGGEEA ETASGGEEAE TASGGEEAGT ASGGEEAGIA SGGEAGTASG GEEAGTASGG
   361  EEAGTASGGD EAWTTSGKEE ADLLGVRQTE YGAVPGERLL EATGKVWVLE EEGDEEREAE
   421  VSPFPKQPQV LGTERTEEAA ESQTAGREAV GGQEAGESFE GQVDLRGKEA EMRQDLGIRA
   481  DRARMEELVQ AEEAQEERGS SRDPVAELPS DGEAEGTADL EATPEARPEE ELTGEESEAA
   541  QTSCGLLGVE WGGLTHSVTK GQGPELMGGA QTPTKQPEER EAGEVELMGV LALSKEEQER
   601  SLEAGPRHAG SVKPEASEAF PGAWENRTRK DMERGNTQED AADGEQREEE ETAGGQTLAA
   661  EAEGDRESEL SEVPEAGGEG LTTQDAGCGT EEGEASVSEN QELDGSTGAD AGPCPSLGEA
   721  YARETEDEEA EADRTSRRGW RLQAVAVGLP DREDAQTGSV AAGIMGGDVV PHISAAGAGE
   781  ALEGVLGQGW DSKEKEEAAA GEHAGGQEFG LEGSAEEEVT GRGSQVEAFE SREGGPWGGR
   841  VEAEESAGAE DSCGLDPAGS QTARAEGMGA MVEAGGLLEK WTLLEEEAVG WQEREQREDS
   901  EGRCGDYHPE GEAPRLLDAE GLMVTGGRRA EAKETEPESL EHVRGQEEQP THQAPAEAAP
   961  ESVGEAETAE AMGSARGGAA NSWSEAPLPG SLLDVSVPRS RVHLSRSSSQ RRSRPSFRRT
  1021  PAWEQQEEPP APNPPEEELS APEQRPLQLE EPLEPSPLRH DGTPVPARRR PLGHGFGLAH
  1081  PGMMQELQAR LGRPKPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOBR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 35 nTPM
  • bone marrow: 33 nTPM
  • colon: 25 nTPM
  • appendix: 19 nTPM
  • rectum: 15 nTPM
  • lung: 11 nTPM

Single-cell type

  • neutrophils: 262 nCPM
  • colonocytes: 111 nCPM
  • goblet cells: 55 nCPM
  • neutrophil progenitors: 55 nCPM
  • monocytes: 54 nCPM
  • tuft cells: 46 nCPM

Immune cell

  • neutrophil: 17 nTPM
  • eosinophil: 16 nTPM
  • basophil: 10 nTPM
  • NK-cell: 7.3 nTPM
  • classical monocyte: 5.8 nTPM
  • myeloid DC: 5 nTPM

Brain region

  • thalamus: 5.3 nTPM
  • medulla oblongata: 4.4 nTPM
  • white matter: 4.2 nTPM
  • pons: 3.4 nTPM
  • hypothalamus: 3.2 nTPM
  • spinal cord: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.77
gnomAD pLI
0
gnomAD missense Z
0.42
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Apolipoprotein B receptor

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APOBR as an antibody target. Whether an autoantibody or antibody against APOBR could matter depends on whether native APOBR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APOBR is annotated at the cell surface, where native APOBR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label APOBR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/APOBR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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