Seroatlas · Human Serome Atlas

APOBEC4

Putative C->U-editing enzyme APOBEC-4

Also known as: ABEC4_HUMAN, C1orf169, FLJ25691, MGC26594, RP1-127C7.4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WW27
Gene: APOBEC4
Ensembl: ENSG00000173627
Chromosome: 1
Canonical length: 367 aa
Protein class: Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

367 residues, UniProt reviewed canonical sequence.

>Q8WW27|APOBEC4
     1  MEPIYEEYLA NHGTIVKPYY WLSFSLDCSN CPYHIRTGEE ARVSLTEFCQ IFGFPYGTTF
    61  PQTKHLTFYE LKTSSGSLVQ KGHASSCTGN YIHPESMLFE MNGYLDSAIY NNDSIRHIIL
   121  YSNNSPCNEA NHCCISKMYN FLITYPGITL SIYFSQLYHT EMDFPASAWN REALRSLASL
   181  WPRVVLSPIS GGIWHSVLHS FISGVSGSHV FQPILTGRAL ADRHNAYEIN AITGVKPYFT
   241  DVLLQTKRNP NTKAQEALES YPLNNAFPGQ FFQMPSGQLQ PNLPPDLRAP VVFVLVPLRD
   301  LPPMHMGQNP NKPRNIVRHL NMPQMSFQET KDLGRLPTGR SVEIVEITEQ FASSKEADEK
   361  KKKKGKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOBEC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 11 nTPM
testis: 9.3 nTPM
lung: 1.1 nTPM
choroid plexus: 0.8 nTPM
endometrium: 0.2 nTPM
cervix: 0.1 nTPM

Single-cell type

early spermatids: 144 nCPM
late spermatids: 116 nCPM
late primary spermatocytes: 89 nCPM
fallopian tube ciliated cells: 88 nCPM
respiratory ciliated cells: 65 nCPM
epididymal efferent duct ciliated cells: 31 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 4.6 nTPM
cerebellum: 4.5 nTPM
cerebral cortex: 3.6 nTPM
hippocampal formation: 3.5 nTPM
white matter: 2.9 nTPM
basal ganglia: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0
gnomAD missense Z: 0.56
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mRNA processing

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Cytidine and deoxycytidylate deaminase domain
Putative deaminase APOBEC-4

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APOBEC4 as an antibody target. Whether an autoantibody or antibody against APOBEC4 could matter depends on whether native APOBEC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APOBEC4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label APOBEC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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