Seroatlas · Human Serome Atlas

APOBEC2

C->U-editing enzyme APOBEC-2

Also known as: ABEC2_HUMAN, ARCD1, ARP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y235
Gene: APOBEC2
Ensembl: ENSG00000124701
Chromosome: 6
Canonical length: 224 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homotetramer

OverviewNCBI Gene

Enables cytidine deaminase activity and identical protein binding activity. Involved in positive regulation of gene expression via chromosomal CpG island demethylation. Acts upstream of or within cytidine to uridine editing. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>Q9Y235|APOBEC2
     1  MAQKEEAAVA TEAASQNGED LENLDDPEKL KELIELPPFE IVTGERLPAN FFKFQFRNVE
    61  YSSGRNKTFL CYVVEAQGKG GQVQASRGYL EDEHAAAHAE EAFFNTILPA FDPALRYNVT
   121  WYVSSSPCAA CADRIIKTLS KTKNLRLLIL VGRLFMWEEP EIQAALKKLK EAGCKLRIMK
   181  PQDFEYVWQN FVEQEEGESK AFQPWEDIQE NFLYYEEKLA DILK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOBEC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 800 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 800 nTPM
tongue: 269 nTPM
heart muscle: 142 nTPM
esophagus: 11 nTPM
thymus: 10 nTPM
pancreas: 9.6 nTPM

Single-cell type

parietal cells: 166 nCPM
thymic myoid cells: 159 nCPM
cardiomyocytes: 122 nCPM
myonuclei: 108 nCPM
pancreatic duct cells: 35 nCPM
late primary spermatocytes: 34 nCPM

Immune cell

plasmacytoid DC: 2.2 nTPM
memory B-cell: 2.1 nTPM
naive B-cell: 1.9 nTPM
naive CD8 T-cell: 1.8 nTPM
memory CD8 T-cell: 1.7 nTPM
gdT-cell: 1.6 nTPM

Brain region

white matter: 5.1 nTPM
medulla oblongata: 3.8 nTPM
basal ganglia: 3.5 nTPM
cerebral cortex: 3.4 nTPM
thalamus: 3.3 nTPM
pons: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0.02
gnomAD missense Z: -0.21
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APOBEC2 as an antibody target. Whether an autoantibody or antibody against APOBEC2 could matter depends on whether native APOBEC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APOBEC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label APOBEC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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