Seroatlas · Human Serome Atlas

APCDD1L

Protein APCDD1-like

Also known as: APCDL_HUMAN, FLJ90166

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCL9
Gene: APCDD1L
Ensembl: ENSG00000198768
Chromosome: 20
Canonical length: 501 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable Wnt-protein binding activity. Predicted to be involved in negative regulation of Wnt signaling pathway. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

501 residues, UniProt reviewed canonical sequence.

>Q8NCL9|APCDD1L
     1  MPAAMLPYAC VLVLLGAHTA PAAGEAGGSC LRWEPHCQQP LPDRVPSTAI LPPRLNGPWI
    61  STGCEVRPGP EFLTRAYTFY PSRLFRAHQF YYEDPFCGEP AHSLLVKGKV RLRRASWVTR
   121  GATEADYHLH KVGIVFHSRR ALVDVTGRLN QTRAGRDCAR RLPPARAWLP GALYELRSAR
   181  AQGDCLEALG LTMHELSLVR VQRRLQPQPR ASPRLVEELY LGDIHTDPAE RRHYRPTGYQ
   241  RPLQSALHHV QPCPACGLIA RSDVHHPPVL PPPLALPLHL GGWWVSSGCE VRPAVLFLTR
   301  LFTFHGHSRS WEGYYHHFSD PACRQPTFTV YAAGRYTRGT PSTRVRGGTE LVFEVTRAHV
   361  TPMDQVTTAM LNFSEPSSCG GAGAWSMGTE RDVTATNGCL PLGIRLPHVE YELFKMEQDP
   421  LGQSLLFIGQ RPTDGSSPDT PEKRPTSYQA PLVLCHGEAP DFSRPPQHRP SLQKHPSTGG
   481  LHIAPFPLLP LVLGLAFLHW L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APCDD1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 18 nTPM
blood vessel: 5.3 nTPM
breast: 4.5 nTPM
urinary bladder: 4 nTPM
kidney: 2.3 nTPM
heart muscle: 1.3 nTPM

Single-cell type

lacrimal acinar cells: 101 nCPM
renal connecting tubule cells: 73 nCPM
corticotrophs: 45 nCPM
breast secretory cells: 34 nCPM
adrenal medulla cells: 21 nCPM
fibro-adipogenic progenitors: 21 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1.8 nTPM
medulla oblongata: 1.3 nTPM
amygdala: 1.1 nTPM
thalamus: 1 nTPM
cerebral cortex: 0.9 nTPM
hippocampal formation: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.06
gnomAD missense Z: 0.38
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APCDD1L as an antibody target. Whether an autoantibody or antibody against APCDD1L could matter depends on whether native APCDD1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APCDD1L is annotated at the cell surface, where native APCDD1L is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label APCDD1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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