Seroatlas · Human Serome Atlas

APCDD1

Protein APCDD1

Also known as: APCD1_HUMAN, B7323

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8J025
Gene
APCDD1
Ensembl
ENSG00000154856
Chromosome
18
Canonical length
514 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

514 residues, UniProt reviewed canonical sequence.

>Q8J025|APCDD1
     1  MSWPRRLLLR YLFPALLLHG LGEGSALLHP DSRSHPRSLE KSAWRAFKES QCHHMLKHLH
    61  NGARITVQMP PTIEGHWVST GCEVRSGPEF ITRSYRFYHN NTFKAYQFYY GSNRCTNPTY
   121  TLIIRGKIRL RQASWIIRGG TEADYQLHNV QVICHTEAVA EKLGQQVNRT CPGFLADGGP
   181  WVQDVAYDLW REENGCECTK AVNFAMHELQ LIRVEKQYLH HNLDHLVEEL FLGDIHTDAT
   241  QRMFYRPSSY QPPLQNAKNH DHACIACRII YRSDEHHPPI LPPKADLTIG LHGEWVSQRC
   301  EVRPEVLFLT RHFIFHDNNN TWEGHYYHYS DPVCKHPTFS IYARGRYSRG VLSSRVMGGT
   361  EFVFKVNHMK VTPMDAATAS LLNVFNGNEC GAEGSWQVGI QQDVTHTNGC VALGIKLPHT
   421  EYEIFKMEQD ARGRYLLFNG QRPSDGSSPD RPEKRATSYQ MPLVQCASSS PRAEDLAEDS
   481  GSSLYGRAPG RHTWSLLLAA LACLVPLLHW NIRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APCDD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
123 nTPM

Expression across tissuesHPA

Tissue

  • skin: 123 nTPM
  • adipose tissue: 49 nTPM
  • urinary bladder: 34 nTPM
  • vagina: 33 nTPM
  • cerebral cortex: 33 nTPM
  • cervix: 33 nTPM

Single-cell type

  • endometrial stromal cells: 475 nCPM
  • decidual stromal cells: 253 nCPM
  • oligodendrocyte progenitor cells: 193 nCPM
  • adipocytes: 178 nCPM
  • astrocytes: 177 nCPM
  • fibroblasts: 137 nCPM

Immune cell

  • basophil: 0.9 nTPM
  • plasmacytoid DC: 0.9 nTPM
  • classical monocyte: 0.2 nTPM
  • total PBMC: 0.2 nTPM
  • naive B-cell: 0.1 nTPM
  • neutrophil: 0.1 nTPM

Brain region

  • hippocampal formation: 66 nTPM
  • midbrain: 62 nTPM
  • cerebral cortex: 58 nTPM
  • thalamus: 55 nTPM
  • amygdala: 54 nTPM
  • medulla oblongata: 54 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about APCDD1.

Disease | AllUniProt

Conditions APCDD1 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 175 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hypotrichosis 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0.01
gnomAD missense Z
0.48
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of APCDD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APCDD1 as an antibody target. Whether an autoantibody or antibody against APCDD1 could matter depends on whether native APCDD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APCDD1 is annotated at the cell surface, where native APCDD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label APCDD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/APCDD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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