Seroatlas · Human Serome Atlas

AOPEP

Aminopeptidase O

Also known as: AMPO_HUMAN, AP-O, APO, C90RF3, C9orf3, FLJ14675

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N6M6
Gene
AOPEP
Ensembl
ENSG00000148120
Chromosome
9
Canonical length
819 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Cell Junctions

OverviewNCBI Gene

This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]

Canonical amino-acid sequenceUniProt

819 residues, UniProt reviewed canonical sequence.

>Q8N6M6|AOPEP
     1  MDIQLDPARD DLPLMANTSH ILVKHYVLDL DVDFESQVIE GTIVLFLEDG NRFKKQNSSI
    61  EEACQSESNK ACKFGMPEPC HIPVTNARTF SSEMEYNDFA ICSKGEKDTS DKDGNHDNQE
   121  HASGISSSKY CCDTGNHGSE DFLLVLDCCD LSVLKVEEVD VAAVPGLEKF TRSPELTVVS
   181  EEFRNQIVRE LVTLPANRWR EQLDYYARCS QAPGCGELLF DTDTWSLQIR KTGAQTATDF
   241  PHAIRIWYKT KPEGRSVTWT SDQSGRPCVY TVGSPINNRA LFPCQEPPVA MSTWQATVRA
   301  AASFVVLMSG ENSAKPTQLW EECSSWYYYV TMPMPASTFT IAVGCWTEMK METWSSNDLA
   361  TERPFSPSEA NFRHVGVCSH MEYPCRFQNA SATTQEIIPH RVFAPVCLTG ACQETLLRLI
   421  PPCLSAAHSV LGAHPFSRLD VLIVPANFPS LGMASPHIMF LSQSILTGGN HLCGTRLCHE
   481  IAHAWFGLAI GARDWTEEWL SEGFATHLED VFWATAQQLA PYEAREQQEL RACLRWRRLQ
   541  DEMQCSPEEM QVLRPSKDKT GHTSDSGASV IKHGLNPEKI FMQVHYLKGY FLLRFLAKRL
   601  GDETYFSFLR KFVHTFHGQL ILSQDFLQML LENIPEEKRL ELSVENIYQD WLESSGIPKP
   661  LQRERRAGAE CGLARQVRAE VTKWIGVNRR PRKRKRREKE EVFEKLLPDQ LVLLLEHLLE
   721  QKTLSPRTLQ SLQRTYHLQD QDAEVRHRWC ELIVKHKFTK AYKSVERFLQ EDQAMGVYLY
   781  GELMVSEDAR QQQLARRCFE RTKEQMDRSS AQVVAEMLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AOPEP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • skin: 36 nTPM
  • blood vessel: 30 nTPM
  • skeletal muscle: 29 nTPM
  • heart muscle: 28 nTPM
  • liver: 23 nTPM
  • placenta: 23 nTPM

Single-cell type

  • myonuclei: 1,087 nCPM
  • oligodendrocytes: 832 nCPM
  • podocytes: 686 nCPM
  • smooth muscle cells: 669 nCPM
  • ependymal cells: 661 nCPM
  • proximal tubule cells: 655 nCPM

Immune cell

  • myeloid DC: 2.2 nTPM
  • naive B-cell: 2.2 nTPM
  • plasmacytoid DC: 2.1 nTPM
  • classical monocyte: 1.4 nTPM
  • NK-cell: 1.4 nTPM
  • gdT-cell: 1.3 nTPM

Brain region

  • white matter: 107 nTPM
  • choroid plexus: 76 nTPM
  • medulla oblongata: 76 nTPM
  • basal ganglia: 67 nTPM
  • cerebral cortex: 65 nTPM
  • pons: 63 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AOPEP.

Disease | AllUniProt

Conditions AOPEP is implicated in, by any mechanism.

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 58 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.94
gnomAD pLI
0
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AOPEP as an antibody target. Whether an autoantibody or antibody against AOPEP could matter depends on whether native AOPEP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AOPEP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AOPEP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AOPEP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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