AOC2

Protein identityUniProt · HPA

UniProt accession

O75106

Gene

AOC2

Ensembl

ENSG00000131480

Chromosome

17

Canonical length

756 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Quaternary structure

Homodimer

OverviewNCBI Gene

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

756 residues, UniProt reviewed canonical sequence.

>O75106|AOC2
     1  MHLKIVLAFL ALSLITIFAL AYVLLTSPGG SSQPPHCPSV SHRAQPWPHP GQSQLFADLS
    61  REELTAVMRF LTQRLGPGLV DAAQAQPSDN CIFSVELQLP PKAAALAHLD RGSPPPAREA
   121  LAIVLFGGQP QPNVSELVVG PLPHPSYMRD VTVERHGGPL PYHRRPVLRA EFTQMWRHLK
   181  EVELPKAPIF LSSTFNYNGS TLAAVHATPR GLRSGDRATW MALYHNISGV GLFLHPVGLE
   241  LLLDHRALDP AHWTVQQVFY LGHYYADLGQ LEREFKSGRL EVVRVPLPPP NGASSLRSRN
   301  SPGPLPPLQF SPQGSQYSVQ GNLVVSSLWS FTFGHGVFSG LRIFDVRFQG ERIAYEVSVQ
   361  ECVSIYGADS PKTMLTRYLD SSFGLGRNSR GLVRGVDCPY QATMVDIHIL VGKGAVQLLP
   421  GAVCVFEEAQ GLPLRRHHNY LQNHFYGGLA SSALVVRSVS SVGNYDYIWD FVLYPNGALE
   481  GRVHATGYIN TAFLKGGEEG LLFGNRVGER VLGTVHTHAF HFKLDLDVAG LKNWVVAEDV
   541  VFKPVAAPWN PEHWLQRPQL TRQVLGKEDL TAFSLGSPLP RYLYLASNQT NAWGHQRGYR
   601  IQIHSPLGIH IPLESDMERA LSWGRYQLVV TQRKEEESQS SSIYHQNDIW TPTVTFADFI
   661  NNETLLGEDL VAWVTASFLH IPHAEDIPNT VTLGNRVGFL LRPYNFFDED PSIFSPGSVY
   721  FEKGQDAGLC SINPVACLPD LAACVPDLPP FSYHGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AOC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

5.5 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.25

gnomAD pLI

0

gnomAD missense Z

-1.22

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• amine metabolic process
• catecholamine metabolic process
• visual perception
• xenobiotic metabolic process

Molecular functions

• copper ion binding
• electron transfer activity
• primary methylamine oxidase activity
• quinone binding

Cellular components

• cytoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Copper amine oxidase
• Copper amine oxidase, catalytic domain
• Copper amine oxidase, N2-terminal
• Copper amine oxidase, N3-terminal
• Copper amine oxidase, N-terminal
• Copper amine oxidase, catalytic domain superfamily
• Copper amine oxidase, copper-binding site
• Copper amine oxidase, TPQ-binding site
• Copper amine oxidase, enzyme domain
• Copper amine oxidase, N2 domain
• Copper amine oxidase, N3 domain

KeywordsUniProt

• Calcium
• Catecholamine metabolism
• Cell membrane
• Copper
• Cytoplasm
• Disulfide bond
• Glycoprotein
• Membrane
• Metal-binding
• Oxidoreductase
• Signal-anchor
• TPQ
• Transmembrane
• Transmembrane helix