AOC1

Protein identityUniProt · HPA

UniProt accession

P19801

Gene

AOC1

Ensembl

ENSG00000002726

Chromosome

7

Canonical length

751 aa

Protein class

Enzymes, Metabolic proteins, Predicted secreted proteins

Secretome location

Secreted in other tissues

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

751 residues, UniProt reviewed canonical sequence.

>P19801|AOC1
     1  MPALGWAVAA ILMLQTAMAE PSPGTLPRKA GVFSDLSNQE LKAVHSFLWS KKELRLQPSS
    61  TTTMAKNTVF LIEMLLPKKY HVLRFLDKGE RHPVREARAV IFFGDQEHPN VTEFAVGPLP
   121  GPCYMRALSP RPGYQSSWAS RPISTAEYAL LYHTLQEATK PLHQFFLNTT GFSFQDCHDR
   181  CLAFTDVAPR GVASGQRRSW LIIQRYVEGY FLHPTGLELL VDHGSTDAGH WAVEQVWYNG
   241  KFYGSPEELA RKYADGEVDV VVLEDPLPGG KGHDSTEEPP LFSSHKPRGD FPSPIHVSGP
   301  RLVQPHGPRF RLEGNAVLYG GWSFAFRLRS SSGLQVLNVH FGGERIAYEV SVQEAVALYG
   361  GHTPAGMQTK YLDVGWGLGS VTHELAPGID CPETATFLDT FHYYDADDPV HYPRALCLFE
   421  MPTGVPLRRH FNSNFKGGFN FYAGLKGQVL VLRTTSTVYN YDYIWDFIFY PNGVMEAKMH
   481  ATGYVHATFY TPEGLRHGTR LHTHLIGNIH THLVHYRVDL DVAGTKNSFQ TLQMKLENIT
   541  NPWSPRHRVV QPTLEQTQYS WERQAAFRFK RKLPKYLLFT SPQENPWGHK RTYRLQIHSM
   601  ADQVLPPGWQ EEQAITWARY PLAVTKYRES ELCSSSIYHQ NDPWHPPVVF EQFLHNNENI
   661  ENEDLVAWVT VGFLHIPHSE DIPNTATPGN SVGFLLRPFN FFPEDPSLAS RDTVIVWPRD
   721  NGPNYVQRWI PEDRDCSMPP PFSYNGTYRP V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AOC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

467 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.97

gnomAD pLI

0

gnomAD missense Z

0.76

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• putrescine metabolic process

Molecular functions

• calcium ion binding
• copper ion binding
• heparin binding
• primary methylamine oxidase activity
• protein homodimerization activity
• quinone binding
• diamine oxidase activity
• histamine oxidase activity
• putrescine oxidase activity

Cellular components

• bicellular tight junction
• extracellular exosome
• extracellular region
• extracellular space
• peroxisome
• plasma membrane
• specific granule lumen

Protein domainsUniProt · Pfam · InterPro

• Copper amine oxidase
• Copper amine oxidase, catalytic domain
• Copper amine oxidase, N2-terminal
• Copper amine oxidase, N3-terminal
• Copper amine oxidase, N-terminal
• Copper amine oxidase, catalytic domain superfamily
• Copper amine oxidase, copper-binding site
• Copper amine oxidase, TPQ-binding site
• Copper amine oxidase, enzyme domain
• Copper amine oxidase, N2 domain
• Copper amine oxidase, N3 domain

KeywordsUniProt

• Calcium
• Cell membrane
• Copper
• Disulfide bond
• Glycoprotein
• Heparin-binding
• Membrane
• Metal-binding
• Oxidoreductase
• Secreted
• Signal
• TPQ