Seroatlas · Human Serome Atlas

AOAH

Acyloxyacyl hydrolase

Also known as: AOAH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P28039
Gene
AOAH
Ensembl
ENSG00000136250
Chromosome
7
Canonical length
575 aa
Protein class
Enzymes, Metabolic proteins, Predicted secreted proteins
Subcellular location
Endoplasmic reticulum,Vesicles
Secretome location
Secreted to blood

OverviewNCBI Gene

This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>P28039|AOAH
     1  MQSPWKILTV APLFLLLSLQ SSASPANDDQ SRPSLSNGHT CVGCVLVVSV IEQLAQVHNS
    61  TVQASMERLC SYLPEKLFLK TTCYLVIDKF GSDIIKLLSA DMNADVVCHT LEFCKQNTGQ
   121  PLCHLYPLPK ETWKFTLQKA RQIVKKSPIL KYSRSGSDIC SLPVLAKICQ KIKLAMEQSV
   181  PFKDVDSDKY SVFPTLRGYH WRGRDCNDSD ESVYPGRRPN NWDVHQDSNC NGIWGVDPKD
   241  GVPYEKKFCE GSQPRGIILL GDSAGAHFHI SPEWITASQM SLNSFINLPT ALTNELDWPQ
   301  LSGATGFLDS TVGIKEKSIY LRLWKRNHCN HRDYQNISRN GASSRNLKKF IESLSRNKVL
   361  DYPAIVIYAM IGNDVCSGKS DPVPAMTTPE KLYSNVMQTL KHLNSHLPNG SHVILYGLPD
   421  GTFLWDNLHN RYHPLGQLNK DMTYAQLYSF LNCLQVSPCH GWMSSNKTLR TLTSERAEQL
   481  SNTLKKIAAS EKFTNFNLFY MDFAFHEIIQ EWQKRGGQPW QLIEPVDGFH PNEVALLLLA
   541  DHFWKKVQLQ WPQILGKENP FNPQIKQVFG DQGGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AOAH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
61 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 61 nTPM
  • bone marrow: 41 nTPM
  • lymph node: 33 nTPM
  • appendix: 32 nTPM
  • gallbladder: 15 nTPM
  • tonsil: 14 nTPM

Single-cell type

  • nk-cells: 1,698 nCPM
  • neutrophils: 1,297 nCPM
  • microglia: 880 nCPM
  • t-cells: 864 nCPM
  • monocytes: 717 nCPM
  • kupffer cells: 632 nCPM

Immune cell

  • classical monocyte: 299 nTPM
  • intermediate monocyte: 252 nTPM
  • total PBMC: 207 nTPM
  • myeloid DC: 183 nTPM
  • non-classical monocyte: 114 nTPM
  • NK-cell: 107 nTPM

Brain region

  • white matter: 21 nTPM
  • medulla oblongata: 18 nTPM
  • pons: 16 nTPM
  • thalamus: 14 nTPM
  • choroid plexus: 13 nTPM
  • spinal cord: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
0.32
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AOAH as an antibody target. Whether an autoantibody or antibody against AOAH could matter depends on whether native AOAH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AOAH is annotated as secreted, so native AOAH circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label AOAH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AOAH. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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