ANXA9

Protein identityUniProt · HPA

UniProt accession

O76027

Gene

ANXA9

Ensembl

ENSG00000143412

Chromosome

1

Canonical length

345 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nuclear speckles,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>O76027|ANXA9
     1  MSVTGGKMAP SLTQEILSHL GLASKTAAWG TLGTLRTFLN FSVDKDAQRL LRAITGQGVD
    61  RSAIVDVLTN RSREQRQLIS RNFQERTQQD LMKSLQAALS GNLERIVMAL LQPTAQFDAQ
   121  ELRTALKASD SAVDVAIEIL ATRTPPQLQE CLAVYKHNFQ VEAVDDITSE TSGILQDLLL
   181  ALAKGGRDSY SGIIDYNLAE QDVQALQRAE GPSREETWVP VFTQRNPEHL IRVFDQYQRS
   241  TGQELEEAVQ NRFHGDAQVA LLGLASVIKN TPLYFADKLH QALQETEPNY QVLIRILISR
   301  CETDLLSIRA EFRKKFGKSL YSSLQDAVKG DCQSALLALC RAEDM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANXA9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

34 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.43

gnomAD pLI

0

gnomAD missense Z

0.34

DepMap mean gene effect

-0.14

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell adhesion
• cell-cell adhesion

Molecular functions

• acetylcholine receptor activity
• calcium ion binding
• calcium-dependent phospholipid binding
• phosphatidylserine binding
• phospholipid binding

Cellular components

• cell surface
• cytoplasm
• cytosol
• lateral plasma membrane
• nucleus
• plasma membrane
• synapse
• vesicle membrane

Protein domainsUniProt · Pfam · InterPro

• Annexin
• Annexin repeat, conserved site
• Annexin repeat
• Annexin superfamily
• Annexin
• Annexin A9

KeywordsUniProt

• Annexin
• Cell membrane
• Membrane
• Repeat

InteractionsUniProt · HPA

Protein binding partners of ANXA9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PPL