ANXA8L1
Annexin A8-like protein 1
Also known as: ANXA8L2, AXA81_HUMAN, bA145E20.2, bA301J7.3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5VT79
- Gene
- ANXA8L1
- Ensembl
- ENSG00000264230
- Chromosome
- 10
- Canonical length
- 327 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Apr 2014]
Canonical amino-acid sequenceUniProt
327 residues, UniProt reviewed canonical sequence.
>Q5VT79|ANXA8L1
1 MAWWKAWIEQ EGVTVKSSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK RSNTQRQQIA
61 KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYRYEAK ELHDAMKGLG TKEGVIIEIL
121 ASRTKNQLRE IMKAYEEDYG SSLEEDIQAD TSGYLERILV CLLQGSRDDV SSFVDPALAL
181 QDAQDLYAAG EKIRGTDEMK FITILCTRSA THLLRVFEEY EKIANKSIED SIKSETHGSL
241 EEAMLTVVKC TQNLHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKCHFKKMYG
301 KTLSSMIMED TSGDYKNALL SLVGSDPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ANXA8L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 307 nTPM
Expression across tissuesHPA
Tissue
- skin: 307 nTPM
- esophagus: 175 nTPM
- vagina: 89 nTPM
- cervix: 72 nTPM
- adipose tissue: 37 nTPM
- urinary bladder: 35 nTPM
Single-cell type
- epicardial cells: 34 nCPM
- suprabasal keratinocytes: 6.7 nCPM
- medullary thymic epithelial cells: 4.8 nCPM
- mesothelial cells: 4.7 nCPM
- ocular epithelial cells: 4.5 nCPM
- alveolar cells type 1: 4.2 nCPM
Immune cell
- myeloid DC: 2.1 nTPM
- classical monocyte: 1.2 nTPM
- eosinophil: 0.4 nTPM
- NK-cell: 0.4 nTPM
- total PBMC: 0.2 nTPM
- basophil: 0 nTPM
Brain region
- cerebral cortex: 0.2 nTPM
- hippocampal formation: 0.1 nTPM
- pons: 0.1 nTPM
- white matter: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.84
- gnomAD pLI
- 0.33
- gnomAD missense Z
- 0.45
- DepMap mean gene effect
- -0.26
- DepMap dependency class
- selective
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ANXA8L1 as an antibody target. Whether an autoantibody or antibody against ANXA8L1 could matter depends on whether native ANXA8L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ANXA8L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ANXA8L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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