ANXA8

Protein identityUniProt · HPA

UniProt accession

P13928

Gene

ANXA8

Ensembl

ENSG00000265190

Chromosome

10

Canonical length

327 aa

Protein class

Predicted intracellular proteins

Subcellular location

Vesicles

OverviewNCBI Gene

This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>P13928|ANXA8
     1  MAWWKSWIEQ EGVTVKSSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK RSNTQRQQIA
    61  KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYRYEAK ELHDAMKGLG TKEGVIIEIL
   121  ASRTKNQLRE IMKAYEEDYG SSLEEDIQAD TSGYLERILV CLLQGSRDDV SSFVDPGLAL
   181  QDAQDLYAAG EKIRGTDEMK FITILCTRSA THLLRVFEEY EKIANKSIED SIKSETHGSL
   241  EEAMLTVVKC TQNLHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKCHFKKMYG
   301  KTLSSMIMED TSGDYKNALL SLVGSDP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANXA8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

252 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for ANXA8 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect

-0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• blood coagulation
• endosomal transport
• endosome organization

Molecular functions

• actin filament binding
• calcium ion binding
• calcium-dependent phospholipid binding
• phosphatidylinositol-3,4,5-trisphosphate binding
• phosphatidylinositol-3,4-bisphosphate binding
• phosphatidylinositol-4,5-bisphosphate binding
• phosphatidylserine binding
• phospholipase A2 inhibitor activity

Cellular components

• cytoplasm
• cytosol
• extracellular matrix
• late endosome membrane
• plasma membrane
• sarcolemma
• vesicle membrane

Protein domainsUniProt · Pfam · InterPro

• Annexin
• Annexin A8
• Annexin repeat, conserved site
• Annexin repeat
• Annexin superfamily
• Annexin

KeywordsUniProt

• Annexin
• Blood coagulation
• Calcium
• Calcium/phospholipid-binding
• Hemostasis
• Metal-binding
• Repeat