Seroatlas · Human Serome Atlas

ANXA3

Annexin A3

Also known as: ANX3, ANXA3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P12429
Gene: ANXA3
Ensembl: ENSG00000138772
Chromosome: 4
Canonical length: 323 aa
Protein class: FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>P12429|ANXA3
     1  MASIWVGHRG TVRDYPDFSP SVDAEAIQKA IRGIGTDEKM LISILTERSN AQRQLIVKEY
    61  QAAYGKELKD DLKGDLSGHF EHLMVALVTP PAVFDAKQLK KSMKGAGTNE DALIEILTTR
   121  TSRQMKDISQ AYYTVYKKSL GDDISSETSG DFRKALLTLA DGRRDESLKV DEHLAKQDAQ
   181  ILYKAGENRW GTDEDKFTEI LCLRSFPQLK LTFDEYRNIS QKDIVDSIKG ELSGHFEDLL
   241  LAIVNCVRNT PAFLAERLHR ALKGIGTDEF TLNRIMVSRS EIDLLDIRTE FKKHYGYSLY
   301  SAIKSDTSGD YEITLLKICG GDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANXA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 319 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 319 nTPM
lung: 136 nTPM
salivary gland: 114 nTPM
stomach: 85 nTPM
thyroid gland: 79 nTPM
placenta: 77 nTPM

Single-cell type

neutrophil progenitors: 1,296 nCPM
alveolar cells type 1: 817 nCPM
neutrophils: 784 nCPM
esophageal apical cells: 751 nCPM
megakaryocytes: 464 nCPM
pancreatic duct cells: 371 nCPM

Immune cell

neutrophil: 209 nTPM
total PBMC: 2.9 nTPM
non-classical monocyte: 0.6 nTPM
basophil: 0.5 nTPM
memory B-cell: 0.5 nTPM
naive B-cell: 0.3 nTPM

Brain region

hypothalamus: 24 nTPM
pons: 22 nTPM
thalamus: 21 nTPM
medulla oblongata: 18 nTPM
basal ganglia: 15 nTPM
amygdala: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANXA3 as an antibody target. Whether an autoantibody or antibody against ANXA3 could matter depends on whether native ANXA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANXA3 is annotated at the cell surface, where native ANXA3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ANXA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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