Seroatlas · Human Serome Atlas

ANXA2R

Annexin-2 receptor

Also known as: AX2R_HUMAN, AXIIR, C5orf39

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q3ZCQ2
Gene
ANXA2R
Ensembl
ENSG00000177721
Chromosome
5
Canonical length
193 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol,Cytoplasmic bodies

OverviewNCBI Gene

Predicted to enable signaling receptor activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>Q3ZCQ2|ANXA2R
     1  MEQHFLGCVK RAWDSAEVAP EPQPPPIVSS EDRGPWPLPL YPVLGEYSLD SCDLGLLSSP
    61  CWRLPGVYWQ NGLSPGVQST LEPSTAKPTE FSWPGTQKQQ EAPVEEVGQA EEPDRLRLQQ
   121  LPWSSPLHPW DRQQDTEVCD SGCLLERRHP PALQPWRHLP GFSDCLEWIL RVGFAAFSVL
   181  WACCSRICGA KQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANXA2R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 24 nTPM
  • thymus: 24 nTPM
  • spleen: 21 nTPM
  • bone marrow: 19 nTPM
  • tonsil: 16 nTPM
  • appendix: 11 nTPM

Single-cell type

  • podocytes: 1.3 nCPM
  • t-cells: 1.1 nCPM
  • nk-cells: 1 nCPM
  • renal collecting duct principal cells: 1 nCPM
  • thymocytes: 0.8 nCPM
  • renal connecting tubule cells: 0.6 nCPM

Immune cell

  • naive CD4 T-cell: 97 nTPM
  • naive CD8 T-cell: 72 nTPM
  • T-reg: 67 nTPM
  • MAIT T-cell: 64 nTPM
  • memory CD8 T-cell: 60 nTPM
  • memory CD4 T-cell: 56 nTPM

Brain region

  • white matter: 4.6 nTPM
  • choroid plexus: 3.8 nTPM
  • spinal cord: 3.7 nTPM
  • medulla oblongata: 3.6 nTPM
  • midbrain: 3.3 nTPM
  • thalamus: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
0.07
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

  • Annexin-2 receptor
  • Annexin-2 receptor

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANXA2R as an antibody target. Whether an autoantibody or antibody against ANXA2R could matter depends on whether native ANXA2R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANXA2R is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANXA2R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANXA2R. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...