Seroatlas · Human Serome Atlas

ANXA2P2

Putative annexin A2-like protein

Also known as: AXA2L_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NMY6
Gene: ANXA2P2
Canonical length: 339 aa

OverviewNCBI Gene

No narrative summary is available for ANXA2P2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>A6NMY6|ANXA2P2
     1  MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG VDEVTIVNIV
    61  TNRDNAQRQD IVFSYQRRTK KELASALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG
   121  LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA
   181  EDGSVIDYEL IDQDAQDLYD AGVKRKGTDV PKWISIMTER SVPHLQKVFD RYKSYSPYDM
   241  LESIRKEVKG DLENAFLNLV QRIQNKPLYF ADQLYDSMKG KGTRDKVLIR IMVSRSEVDM
   301  LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANXA2P2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ANXA2P2.

Disease | ImmuneIEDB

Conditions an epitope on ANXA2P2 was assayed in.

type 1 diabetes mellitus T cell

OntologyGO

Biological processes

cell adhesion
negative regulation of transport
positive regulation of plasminogen activation
positive regulation of vesicle fusion
positive regulation of multicellular organismal process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANXA2P2 as an antibody target. Whether an autoantibody or antibody against ANXA2P2 could matter depends on whether native ANXA2P2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANXA2P2 is annotated at the cell surface, where native ANXA2P2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ANXA2P2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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