Seroatlas · Human Serome Atlas

ANXA13

Annexin A13

Also known as: ANX13, ANX13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P27216
Gene: ANXA13
Ensembl: ENSG00000104537
Chromosome: 8
Canonical length: 316 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>P27216|ANXA13
     1  MGNRHAKASS PQGFDVDRDA KKLNKACKGM GTNEAAIIEI LSGRTSDERQ QIKQKYKATY
    61  GKELEEVLKS ELSGNFEKTA LALLDRPSEY AARQLQKAMK GLGTDESVLI EVLCTRTNKE
   121  IIAIKEAYQR LFDRSLESDV KGDTSGNLKK ILVSLLQANR NEGDDVDKDL AGQDAKDLYD
   181  AGEGRWGTDE LAFNEVLAKR SYKQLRATFQ AYQILIGKDI EEAIEEETSG DLQKAYLTLV
   241  RCAQDCEDYF AERLYKSMKG AGTDEETLIR IVVTRAEVDL QGIKAKFQEK YQKSLSDMVR
   301  SDTSGDFRKL LVALLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANXA13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 276 nTPM

Expression across tissuesHPA

Tissue

duodenum: 276 nTPM
small intestine: 207 nTPM
gallbladder: 136 nTPM
fallopian tube: 55 nTPM
rectum: 34 nTPM
seminal vesicle: 23 nTPM

Single-cell type

tuft cells: 484 nCPM
fallopian tube ciliated cells: 184 nCPM
goblet cells: 173 nCPM
epididymal efferent duct ciliated cells: 165 nCPM
cholangiocytes: 161 nCPM
enterocytes: 129 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 8.5 nTPM
medulla oblongata: 6.8 nTPM
pons: 4.9 nTPM
spinal cord: 4.8 nTPM
midbrain: 4.2 nTPM
basal ganglia: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: -0.43
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANXA13 as an antibody target. Whether an autoantibody or antibody against ANXA13 could matter depends on whether native ANXA13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANXA13 is annotated at the cell surface, where native ANXA13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ANXA13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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