Seroatlas · Human Serome Atlas

ANXA10

Annexin A10

Also known as: ANX10_HUMAN, ANX14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UJ72
Gene: ANXA10
Ensembl: ENSG00000109511
Chromosome: 4
Canonical length: 324 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Vesicles

OverviewNCBI Gene

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

324 residues, UniProt reviewed canonical sequence.

>Q9UJ72|ANXA10
     1  MFCGDYVQGT IFPAPNFNPI MDAQMLGGAL QGFDCDKDML INILTQRCNA QRMMIAEAYQ
    61  SMYGRDLIGD MREQLSDHFK DVMAGLMYPP PLYDAHELWH AMKGVGTDEN CLIEILASRT
   121  NGEIFQMREA YCLQYSNNLQ EDIYSETSGH FRDTLMNLVQ GTREEGYTDP AMAAQDAMVL
   181  WEACQQKTGE HKTMLQMILC NKSYQQLRLV FQEFQNISGQ DMVDAINECY DGYFQELLVA
   241  IVLCVRDKPA YFAYRLYSAI HDFGFHNKTV IRILIARSEI DLLTIRKRYK ERYGKSLFHD
   301  IRNFASGHYK KALLAICAGD AEDY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANXA10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 459 nTPM

Expression across tissuesHPA

Tissue

stomach: 459 nTPM
urinary bladder: 84 nTPM
duodenum: 19 nTPM
testis: 0.9 nTPM
pancreas: 0.6 nTPM
gallbladder: 0.4 nTPM

Single-cell type

foveolar cells: 1,701 nCPM
parietal cells: 705 nCPM
mucous neck cells: 588 nCPM
gastric chief cells: 355 nCPM
gastric progenitor cells: 297 nCPM
urothelial cells: 253 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.2 nTPM
medulla oblongata: 0.2 nTPM
midbrain: 0.2 nTPM
pons: 0.2 nTPM
spinal cord: 0.2 nTPM
amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANXA10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

EDC3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANXA10 as an antibody target. Whether an autoantibody or antibody against ANXA10 could matter depends on whether native ANXA10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANXA10 is annotated at the cell surface, where native ANXA10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ANXA10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...