Seroatlas · Human Serome Atlas

ANTXRL

Anthrax toxin receptor-like

Also known as: ANTRL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NF34
Gene: ANTXRL
Ensembl: ENSG00000274209
Chromosome: 10
Canonical length: 631 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable transmembrane signaling receptor activity. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

631 residues, UniProt reviewed canonical sequence.

>A6NF34|ANTXRL
     1  MGSHESLGPY FLVFLLLLLL PPPLFRAGSL RYHGPDWRIF HRLALGSRRA HHHHGPGWRQ
    61  HWRQGQAGHR CQGSFDLYFI LDKSGSVNNN WIDLYMWVEE TVARFQSPNI RMCFITYSTD
   121  GQTVLPLTSD KNRIKNGLDQ LQKIVPDGHT FMQAGFRKAI QQIESFNSGN KVPSMIIAMT
   181  DGELVAHAFQ DTLREAQKAR KLGANVYTLG VADYNLDQIT AIADSPGHVF AVENGFKALR
   241  STIDALTSKV CLDVTSVEPS SECVGEPYHV VIHGNGFQNL KKRDEVICRF IFNESTIIDE
   301  KPTSIDNNSM NCPGPKLEKP GEEYSIEVSL NKGKTFFKSN VSITSTTCGI FRNWLYFVPL
   361  LLLVPLLLCC VWRLCRKQTV KEPPPVQKPE KEPEQEKPPS PPPPPPPPPP PLPPPPPAPV
   421  NTCPTVIICC CGCQGVGGMR RIEGNLDTFC DLSHASCHQV PWMCCQSRDQ GRYLSLALAQ
   481  SQYAQAPCCP RICFPHSQEC LSLPQAPCSP RMCLRHSREC LALKQARCSP NICLRHSQHS
   541  RECLARKQAP CSPRICLRHS PEYFSQAQTL CNPKSCLQPS RECLPLTCSS RCRLPPARCL
   601  RPPSRMLPLL SPLLRHTAEP PLSLPPSEPN F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANTXRL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
bone marrow: 0.9 nTPM
fallopian tube: 0.3 nTPM
breast: 0.2 nTPM
cervix: 0.1 nTPM
endometrium: 0.1 nTPM

Single-cell type

early spermatids: 71 nCPM
late spermatids: 50 nCPM
late primary spermatocytes: 41 nCPM
sertoli cells: 20 nCPM
neutrophil progenitors: 5.4 nCPM
epicardial cells: 2.3 nCPM

Immune cell

neutrophil: 1.1 nTPM
basophil: 0.5 nTPM
eosinophil: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

medulla oblongata: 0.6 nTPM
white matter: 0.4 nTPM
pons: 0.3 nTPM
thalamus: 0.3 nTPM
basal ganglia: 0.2 nTPM
cerebellum: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.93
gnomAD pLI: 0
gnomAD missense Z: 1.35
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANTXRL as an antibody target. Whether an autoantibody or antibody against ANTXRL could matter depends on whether native ANTXRL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANTXRL is annotated at the cell surface, where native ANTXRL is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ANTXRL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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