Seroatlas · Human Serome Atlas

ANTXR2

Anthrax toxin receptor 2

Also known as: ANTR2_HUMAN, CMG-2, CMG2, FLJ31074

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P58335
Gene: ANTXR2
Ensembl: ENSG00000163297
Chromosome: 4
Canonical length: 489 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

489 residues, UniProt reviewed canonical sequence.

>P58335|ANTXR2
     1  MVAERSPARS PGSWLFPGLW LLVLSGPGGL LRAQEQPSCR RAFDLYFVLD KSGSVANNWI
    61  EIYNFVQQLA ERFVSPEMRL SFIVFSSQAT IILPLTGDRG KISKGLEDLK RVSPVGETYI
   121  HEGLKLANEQ IQKAGGLKTS SIIIALTDGK LDGLVPSYAE KEAKISRSLG ASVYCVGVLD
   181  FEQAQLERIA DSKEQVFPVK GGFQALKGII NSILAQSCTE ILELQPSSVC VGEEFQIVLS
   241  GRGFMLGSRN GSVLCTYTVN ETYTTSVKPV SVQLNSMLCP APILNKAGET LDVSVSFNGG
   301  KSVISGSLIV TATECSNGIA AIIVILVLLL LLGIGLMWWF WPLCCKVVIK DPPPPPAPAP
   361  KEEEEEPLPT KKWPTVDASY YGGRGVGGIK RMEVRWGDKG STEEGARLEK AKNAVVKIPE
   421  ETEEPIRPRP PRPKPTHQPP QTKWYTPIKG RLDALWALLR RQYDRVSLMR PQEGDEVCIW
   481  ECIEKELTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANTXR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 103 nTPM

Expression across tissuesHPA

Tissue

prostate: 103 nTPM
smooth muscle: 101 nTPM
endometrium: 89 nTPM
seminal vesicle: 85 nTPM
placenta: 85 nTPM
colon: 84 nTPM

Single-cell type

neutrophils: 1,151 nCPM
neutrophil progenitors: 1,005 nCPM
prostatic glandular cells: 604 nCPM
fibro-adipogenic progenitors: 396 nCPM
monocytes: 386 nCPM
cone photoreceptor cells: 292 nCPM

Immune cell

basophil: 73 nTPM
eosinophil: 62 nTPM
neutrophil: 55 nTPM
T-reg: 40 nTPM
myeloid DC: 32 nTPM
plasmacytoid DC: 32 nTPM

Brain region

cerebral cortex: 11 nTPM
spinal cord: 9.4 nTPM
hypothalamus: 8.8 nTPM
choroid plexus: 8.3 nTPM
midbrain: 8.3 nTPM
medulla oblongata: 7.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ANTXR2.

Disease | AllUniProt

Conditions ANTXR2 is implicated in, by any mechanism.

Hyaline fibromatosis syndrome (HFS) MIM:228600

Disease | GeneticClinVar

40 pathogenic / likely-pathogenic of 315 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hyaline fibromatosis syndrome
Juvenile hyaline fibromatosis
ANTXR2-related disorder
Familial cancer of breast

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.09
gnomAD missense Z: 1.03
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANTXR2 as an antibody target. Whether an autoantibody or antibody against ANTXR2 could matter depends on whether native ANTXR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANTXR2 is annotated at the cell surface, where native ANTXR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ANTXR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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