Seroatlas · Human Serome Atlas

ANTKMT

Adenine nucleotide translocase lysine N-methyltransferase

Also known as: ANKMT_HUMAN, C16orf24, FAM173A, MGC2494

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQD7
Gene: ANTKMT
Ensembl: ENSG00000103254
Chromosome: 16
Canonical length: 235 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine trimethylation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>Q9BQD7|ANTKMT
     1  MEQDDPVEAL TELRERRLGA LELLQAAAGS GLAAYAVWAL LLQPGFRRVP LRLQVPYVGA
    61  SARQVEHVLS LLRGRPGKTV DLGSGDGRIV LAAHRCGLRP AVGYELNPWL VALARLHAWR
   121  AGCAGSVCYR RKDLWKVSLR DCRNVSVFLA PSVLPLLEDK LRTELPAGAR VVSGRFPLPT
   181  WQPVTAVGEG LDRVWAYDVP EGGQAGEAAS SRIPIQAAPG PSSAPIPGGL ISQAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANTKMT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

liver: 42 nTPM
kidney: 37 nTPM
amygdala: 37 nTPM
cerebral cortex: 35 nTPM
hippocampal formation: 34 nTPM
pituitary gland: 31 nTPM

Single-cell type

late spermatids: 785 nCPM
late primary spermatocytes: 424 nCPM
early spermatids: 217 nCPM
enterocytes: 154 nCPM
esophageal suprabasal cells: 118 nCPM
colonocytes: 117 nCPM

Immune cell

naive CD8 T-cell: 27 nTPM
MAIT T-cell: 25 nTPM
T-reg: 23 nTPM
naive B-cell: 22 nTPM
memory CD8 T-cell: 20 nTPM
memory B-cell: 18 nTPM

Brain region

medulla oblongata: 33 nTPM
midbrain: 29 nTPM
white matter: 28 nTPM
thalamus: 26 nTPM
cerebral cortex: 26 nTPM
spinal cord: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein-lysine N-methyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANTKMT as an antibody target. Whether an autoantibody or antibody against ANTKMT could matter depends on whether native ANTKMT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANTKMT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANTKMT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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