ANP32D
Acidic leucine-rich nuclear phosphoprotein 32 family member D
Also known as: AN32D_HUMAN, PP32R2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O95626
- Gene
- ANP32D
- Ensembl
- ENSG00000139223
- Chromosome
- 12
- Canonical length
- 131 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Centrosome
OverviewNCBI Gene
Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is absent in the protein encoded by this gene. This gene does not contain introns. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
131 residues, UniProt reviewed canonical sequence.
>O95626|ANP32D
1 MEMGKWIHLE LRNRTPSDVK ELFLDNSQSN EGKLEGLTDE FEELELLNTI NIGLTSIANL
61 PKLNKLKKLE LSSNRASVGL EVLAEKCPNL IHLNLSGNKI KDLSTIEPLK KLENLESLDL
121 FTCEVTNLNN YLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ANP32D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 0.1 nTPM
Expression across tissuesHPA
Tissue
- ovary: 0.1 nTPM
- testis: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- pituitary stem cells: 0.7 nCPM
- salivary ionocytes: 0.4 nCPM
- thyrotrophs: 0.3 nCPM
- astrocytes: 0.2 nCPM
- bergmann glia: 0.2 nCPM
- ependymal cells: 0.2 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 1.4 nTPM
- pons: 1.4 nTPM
- medulla oblongata: 1.3 nTPM
- white matter: 1.1 nTPM
- amygdala: 0.9 nTPM
- basal ganglia: 0.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -0.62
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ANP32D as an antibody target. Whether an autoantibody or antibody against ANP32D could matter depends on whether native ANP32D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ANP32D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ANP32D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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