Seroatlas · Human Serome Atlas

ANKRD7

Ankyrin repeat domain-containing protein 7

Also known as: ANKR7_HUMAN, TSA806

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92527
Gene: ANKRD7
Ensembl: ENSG00000106013
Chromosome: 7
Canonical length: 254 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to act upstream of or within blastocyst hatching. Located in centrosome and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

254 residues, UniProt reviewed canonical sequence.

>Q92527|ANKRD7
     1  MNKLFSFWKR KNETRSQGYN LREKDLKKLH RAASVGDLKK LKEYLQIKKY DVNMQDKKYR
    61  TPLHLACANG HTDVVLFLIE QQCKINVRDS ENKSPLIKAV QCQNEDCATI LLNFGADPDL
   121  RDIRYNTVLH YAVCGQSLSL VEKLLEYEAD LEAKNKDGYT PLLVAVINNN PKMVKFLLEK
   181  GADVNASDNY QRTALILAVS GEPPCLVKLL LQQGVELCYE GIVDSQLRNM FISMVLLHRY
   241  PQFTASHGKK KHAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 804 nTPM

Expression across tissuesHPA

Tissue

testis: 804 nTPM
epididymis: 1.8 nTPM
thyroid gland: 0.8 nTPM
kidney: 0.7 nTPM
pancreas: 0.6 nTPM
pituitary gland: 0.6 nTPM

Single-cell type

late primary spermatocytes: 7,265 nCPM
early spermatids: 2,845 nCPM
early primary spermatocytes: 1,159 nCPM
late spermatids: 914 nCPM
sertoli cells: 173 nCPM
other brain neurons: 89 nCPM

Immune cell

memory B-cell: 0.9 nTPM
eosinophil: 0.2 nTPM
memory CD8 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM

Brain region

pons: 4.9 nTPM
hypothalamus: 4.8 nTPM
thalamus: 4.3 nTPM
cerebral cortex: 4.2 nTPM
midbrain: 4.2 nTPM
medulla oblongata: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: 0.97
DepMap mean gene effect: 0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD7 as an antibody target. Whether an autoantibody or antibody against ANKRD7 could matter depends on whether native ANKRD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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