Seroatlas · Human Serome Atlas

ANKRD62

Ankyrin repeat domain-containing protein 62

Also known as: ANR62_HUMAN, DKFZp779B1634

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NC57
Gene
ANKRD62
Ensembl
ENSG00000181626
Chromosome
18
Canonical length
917 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Actin filaments

OverviewNCBI Gene

No narrative summary is available for ANKRD62 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

917 residues, UniProt reviewed canonical sequence.

>A6NC57|ANKRD62
     1  MEVRGSFLAA CRRRMATWRK NRDKDGFSNP GYRVRQKDLG MIHKAAIAGD VNKVMESILL
    61  RLNDLNDRDK KNRTALLLAC AHGRPGVVAD LVARKCQLNL TDSENRTALI KAVQCQEEVC
   121  ASILLEHGAN PNVRDMYGNT ALHYAIDNEN ISMARKLLAY GADIEARSQD GHTSLLLAVN
   181  RKKEQMVAFL LKKKPDLTAI DNFGRTALIL AARNGSTSVV YQLLQHNIDV FCQDISGWTA
   241  EDYAVASKFQ AIRGMISEYK ANKRCKSLQN SNSEQDLEMT SEGEQERLEG CESSQPQVEE
   301  KMKKCRNKKM EVSRNVHADD SDNYNDDVDE LIHKIKNRKP DNHQSPGKEN GEFDRLARKT
   361  SNEKSKVKSQ IYFTDDLNDI SGSSEKTSED DELPYSDDEN FMLLIEQSGM ECKDFVSLSK
   421  SKNATAACGR SIEDQKCYCE RLKVKFQKMK NNISVLQKVL SETDKTKSQS EHQNLQGKKK
   481  LCNLRFILQQ QEEERIKAEE LYEKDIEELK IMEEQYRTQT EVKKQSKLTL KSLEVELKTV
   541  RSNSNQNFHT HERERDLWQE NHLMRDEIAR LRLEIDTIKH QNQETENKYF KDIEIIKENN
   601  EDLEKTLKRN EEALTKTITR YSKELNVLMD ENTMLNSELQ KEKQSMSRLE TEMESYRCRL
   661  AAALCDHDQR QSSKRDLQLA FQSTVNEWCH LQEDTNSHIQ ILSQQLSKAE STSSGLETEL
   721  HYEREALKEK TLHIEHMQGV LSRTQRRLED IEHMYQNDQP ILEKYVRKQQ SVEDGLFQLQ
   781  SQNLLYQQQC NDARKKADNQ EKTIINIQVK CEDTVEKLQA ECRKLEENNK GLMKECTLLK
   841  ERQCQYEKEK EEREVVRRQL QREVDDALNK QLLLEAMLEI SSERRINLED EAQSLKKKLG
   901  QMRSQVCMKL SMSTVTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD62 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
1.3 nTPM

Expression across tissuesHPA

Tissue

  • testis: 1.3 nTPM
  • pancreas: 0.9 nTPM
  • esophagus: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • early primary spermatocytes: 105 nCPM
  • pancreatic acinar cells: 39 nCPM
  • late primary spermatocytes: 30 nCPM
  • esophageal apical cells: 23 nCPM
  • differentiating spermatogonia: 19 nCPM
  • undifferentiated spermatogonia: 12 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 4 nTPM
  • pons: 3.1 nTPM
  • white matter: 2.4 nTPM
  • hippocampal formation: 1.9 nTPM
  • medulla oblongata: 1.7 nTPM
  • amygdala: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.3
gnomAD missense Z
2.23
DepMap mean gene effect
0.05
DepMap dependency class
none

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD62 as an antibody target. Whether an autoantibody or antibody against ANKRD62 could matter depends on whether native ANKRD62 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD62 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD62 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANKRD62. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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