Seroatlas · Human Serome Atlas

ANKRD55

Ankyrin repeat domain-containing protein 55

Also known as: ANR55_HUMAN, FLJ11795

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3KP44
Gene: ANKRD55
Ensembl: ENSG00000164512
Chromosome: 5
Canonical length: 614 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles,Cytosol

OverviewNCBI Gene

No narrative summary is available for ANKRD55 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

614 residues, UniProt reviewed canonical sequence.

>Q3KP44|ANKRD55
     1  MMRQATMDFS TPSVFDQQRG DSSEEVDLTM VYQAASNGDV NALTAVIRED PSILECCDSE
    61  GCTPLMHAVS GRQADTVKLL LKMGANINMQ DAYGRTSLCL ATYLGWLEGC VSLLRNGAKH
   121  NIPDKNGRLP LHAATAEPDM RLLTVLLQQS NISEINHQDN EGMTPLHWAA FHNQPQHTQM
   181  LLKKGADPTL VDKDFKTALH WAVQSGNRIL CSIILSHHQG PSIINYDDES GKTCVHIAAA
   241  AGFSDIIHEL ARVPECNLQA LDVDDRTPLH WAAAAGKAEC VQSLLELGMD SNLRDINEST
   301  PLAYALYCGH TACVKLLSQE SRTEPTRPPP SQSSRPQKKE RRFNVLNQIF CKNKKEEQRA
   361  HQKDPSRDRY REEDTSEVND IITTFDSIVG TNCQEQPGDQ VAMVEFKKKT SDNSKYLLPE
   421  KKPLARKGLP PIRTQSLPPI TLGNNFLTAS HRATSHAGLS SAPHHMAQRS QKSRSEQDLL
   481  NNRTGCQMLL DNPWKSDSNQ VFSYKVWTVS SSDKLLDRLL SVRPGHQEVS VPPHLRHLHN
   541  PSSGQNFQHL SPNRHKIRDL PFTRNNLAPL PDQKFLSGEP LRTNRVLPAI PSQRRHSTAA
   601  EESEHSANPT SDEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD55 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 9.2 nTPM

Expression across tissuesHPA

Tissue

testis: 9.2 nTPM
hypothalamus: 3.8 nTPM
lymph node: 3.4 nTPM
thymus: 3 nTPM
liver: 2.9 nTPM
basal ganglia: 2.6 nTPM

Single-cell type

endometrial glandular cells: 211 nCPM
late primary spermatocytes: 179 nCPM
early spermatids: 152 nCPM
epicardial cells: 139 nCPM
brain inhibitory neurons: 84 nCPM
platelets: 81 nCPM

Immune cell

basophil: 23 nTPM
eosinophil: 21 nTPM
naive CD4 T-cell: 20 nTPM
memory CD4 T-cell: 4.3 nTPM
total PBMC: 2.8 nTPM
neutrophil: 2 nTPM

Brain region

hypothalamus: 19 nTPM
pons: 13 nTPM
midbrain: 12 nTPM
medulla oblongata: 11 nTPM
spinal cord: 9.1 nTPM
basal ganglia: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0
gnomAD missense Z: 0.17
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD55 as an antibody target. Whether an autoantibody or antibody against ANKRD55 could matter depends on whether native ANKRD55 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD55 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD55 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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