Seroatlas · Human Serome Atlas

ANKRD40CL

Putative ANKRD40 C-terminal-like protein

Also known as: AK40L_HUMAN, C17orf73, FLJ20694, LINC00483

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q53H64
Gene
ANKRD40CL
Ensembl
ENSG00000167117
Chromosome
17
Canonical length
114 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ANKRD40CL in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

114 residues, UniProt reviewed canonical sequence.

>Q53H64|ANKRD40CL
     1  MAEPEQDIGE KPAVRIQNPK ENDFIEIELK RQELSYQNLL NVSCCELGIK PERVEKIRKL
    61  PNTLLRKDKD IRRLRDFQEV ELILMKNGSS RLTEYVPSLT ERPCYDSKAA KMTY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD40CL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 56 nTPM
  • duodenum: 56 nTPM
  • colon: 25 nTPM
  • rectum: 20 nTPM
  • bone marrow: 3.8 nTPM
  • stomach: 2.6 nTPM

Single-cell type

  • enterocytes: 289 nCPM
  • colonocytes: 144 nCPM
  • tuft cells: 58 nCPM
  • enteric transient amplifying cells: 56 nCPM
  • paneth cells: 50 nCPM
  • goblet cells: 46 nCPM

Immune cell

  • basophil: 3.8 nTPM
  • neutrophil: 2.6 nTPM
  • classical monocyte: 0.8 nTPM
  • naive B-cell: 0.7 nTPM
  • NK-cell: 0.7 nTPM
  • plasmacytoid DC: 0.7 nTPM

Brain region

  • medulla oblongata: 20 nTPM
  • cerebellum: 19 nTPM
  • pons: 16 nTPM
  • midbrain: 16 nTPM
  • white matter: 15 nTPM
  • choroid plexus: 14 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD40CL as an antibody target. Whether an autoantibody or antibody against ANKRD40CL could matter depends on whether native ANKRD40CL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD40CL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD40CL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANKRD40CL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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