Seroatlas · Human Serome Atlas

ANKRD39

Ankyrin repeat domain-containing protein 39

Also known as: ANR39_HUMAN, MGC41816

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q53RE8
Gene
ANKRD39
Ensembl
ENSG00000213337
Chromosome
2
Canonical length
183 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

No narrative summary is available for ANKRD39 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>Q53RE8|ANKRD39
     1  MATPRPCADG PCCSHPSAVL GVQQTLEEMD FERGIWSAAL NGDLGRVKHL IQKAEDPSQP
    61  DSAGYTALHY ASRNGHYAVC QFLLESGAKC DAQTHGGATA LHRASYCGHT EIARLLLSHG
   121  SNPRVVDDDG MTSLHKAAER GHGDICSLLL QHSPALKAIR DRKARLACDL LPCNSDLRDL
   181  LSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 23 nTPM
  • cerebellum: 21 nTPM
  • amygdala: 20 nTPM
  • basal ganglia: 18 nTPM
  • hypothalamus: 18 nTPM
  • hippocampal formation: 18 nTPM

Single-cell type

  • oocytes: 14 nCPM
  • gastric chief cells: 13 nCPM
  • melanocytes: 8.7 nCPM
  • suprabasal keratinocytes: 7 nCPM
  • thymic myoid cells: 6.8 nCPM
  • endometrial secretory cells: 5.5 nCPM

Immune cell

  • T-reg: 71 nTPM
  • plasmacytoid DC: 71 nTPM
  • gdT-cell: 45 nTPM
  • memory CD4 T-cell: 44 nTPM
  • memory B-cell: 42 nTPM
  • memory CD8 T-cell: 39 nTPM

Brain region

  • cerebellum: 23 nTPM
  • cerebral cortex: 20 nTPM
  • white matter: 19 nTPM
  • pons: 18 nTPM
  • hypothalamus: 17 nTPM
  • basal ganglia: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.21
gnomAD pLI
0
gnomAD missense Z
0.18
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD39 as an antibody target. Whether an autoantibody or antibody against ANKRD39 could matter depends on whether native ANKRD39 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD39 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD39 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANKRD39. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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