Seroatlas · Human Serome Atlas

ANKRD36C

Ankyrin repeat domain-containing protein 36C

Also known as: AN36C_HUMAN, DKFZp667P0924

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JPF3
Gene: ANKRD36C
Ensembl: ENSG00000174501
Chromosome: 2
Canonical length: 1778 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable ion channel inhibitor activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1778 residues, UniProt reviewed canonical sequence.

>Q5JPF3|ANKRD36C
     1  MDDKEPKRWP TLRDRLCSDG FLFPQYPIKP YHLKGIHRAV FYRDLEELKF VLLTRYDINK
    61  RDRKERTALH LACATGQPEM VHLLVSRRCE LNLCDREDRT PLIKAVQLRQ EACATLLLQN
   121  GADPNITDVF GRTALHYAVY NEDTSMIEKL LSYGANIEEC SEDEYPPLFL AVSQRKVKMV
   181  EFLLKKKANI NAVDYLGRSA LIHAVTLGEK DIVILLLQHN IDVFSRDVYG KLAEDYASEA
   241  KNRVIFELIY EYERKKHEEL SINSNPVSSQ KQPALKATSG KEDSISNIAT EIKDGQKSGT
   301  VSSQKQPALK GTSDKNDSVS NTATEIKDEQ KSGTVSSQKQ PALKDTSDKN DSVSNTATEI
   361  KDEQKSGTVL PAVEQCLNRS LYRPDAVAQP VTEDEFALES EIISKLYIPK RKIISPRSIE
   421  DVLPPVEEAV DRCLYLLDRF AQAVTKDKFA LESENISEPY FTNRRTISQQ SAEKLDAACG
   481  IDKTENGTLF EDQNVDKEGK ALPATGQKAN VSPEQPPLFT HTVKDSDHIS TRFLGSMDSL
   541  TSSEESSERP PLSTLTLKEA DPSSKAAMRR KDSPPPGKVS SQKQPAEKAT SDDKDSVSNI
   601  ATEIKEGPIS GTVSSQKQPA EKATSDEKDS VSNIATEIKE GQQSGTVSPQ KQSAWKVIFK
   661  KKVSLLNIAT RITGGGKSGT VSSQKQPPSK ATSDKTDSAL NIATEIKDGL QCGTVSSQKQ
   721  PALKATTDEE DSVSNIATEI KDGEKSGTVS SQKQPALKAT TDEEDSVSII ATEIKDGEKS
   781  GTVSSRKKPA LKATSDEKDS FSNITREKKD GEISRTVTSE KPAGLKATSD EEDSVLNIAR
   841  GKEDGEKTRR VSSRKKPALK ATSDEKDSFS NITREKKDGE TSRTVSSQKP PALKATSDEE
   901  DSVLNIAREK KDGEKSRTVS SEKPSGLKAT SDEKDSVLNI ARGKKHGEKT RRVSSHKQPA
   961  LKATSDKENS VPNMATETKD EQISGTVSSQ KQPALKATSD KKDSVSNIPT EIKDGQQSGT
  1021  VSSQKQLAWK ATSVKKDSVS NIATEIKDGQ IRGTVSSQRQ PALKATGDEK DSVSNIAREI
  1081  KDGEKSGTVS PQKQSAQKVI FKKKVSLLNI ATRITGGWKS GTEYPENLPT LKATIENKNS
  1141  VLNTATKMKD VQTSTPEQDL EMASEGEQKR LEEYENNQPQ VKNQIHSRDD LDDIIQSSQT
  1201  VSEDGDSLCC NCKNVILLID QHEMKCKDCV HLLKIKKTFC LCKRLTELKD NHCEQLRVKI
  1261  RKLKNKASVL QKRLSEKEEI KSQLKHETLE LEKELCSLRF AIQQEKKKRR NVEELHQKVR
  1321  EKLRITEEQY RIEADVTKPI KPALKSAEVE LKTGGNNSNQ VSETDEKEDL LHENRLMQDE
  1381  IARLRLEKDT IKNQNLEKKY LKDFEIVKRK HEDLQKALKR NEETLAETIA CYSGQLAALT
  1441  DENTTLRSKL EKQRESGQRL ETEMQSYRCR LNAALCDHDQ SHSSKRDQEL AFQGTVDKCC
  1501  HLQENLNSHV LILSLQLSKA ESKFRVLETE LHYTGEALKE KALVFEHVQS ELKQKQSQMK
  1561  DIEKMYKSGY NTMEKCIEKQ ERFCQLKKQN MLLQQQLDDA RNKADNQEKA ILNIQARCDA
  1621  RVENLQAECR KHRLLLEEDN KMLVNELNHS KEKKCQYEKE KAEREVAVRQ LQQKQDDVLN
  1681  KRSATKALLD ASSRHCIYLE NGMQDSRKKL DQMRSQFQEI QDQLTATIRC TKEMEGDAQK
  1741  LEVENVMMRK IIKKQDEQIE RFEKILQHSS LMLQVFES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD36C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 15 nTPM
bone marrow: 14 nTPM
testis: 11 nTPM
retina: 9 nTPM
thymus: 6.1 nTPM
breast: 5.4 nTPM

Single-cell type

sertoli cells: 1,194 nCPM
foveolar cells: 1,110 nCPM
salivary acinar cells: 1,052 nCPM
lacrimal acinar cells: 402 nCPM
submucosal glandular cells: 384 nCPM
salivary duct cells: 354 nCPM

Immune cell

basophil: 48 nTPM
plasmacytoid DC: 33 nTPM
gdT-cell: 20 nTPM
naive B-cell: 19 nTPM
memory B-cell: 16 nTPM
memory CD4 T-cell: 15 nTPM

Brain region

cerebellum: 85 nTPM
white matter: 83 nTPM
pons: 63 nTPM
medulla oblongata: 58 nTPM
cerebral cortex: 57 nTPM
hypothalamus: 57 nTPM

OntologyGO

Molecular functions

ion channel inhibitor activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD36C as an antibody target. Whether an autoantibody or antibody against ANKRD36C could matter depends on whether native ANKRD36C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD36C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD36C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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