Seroatlas · Human Serome Atlas

ANKRD36B

Ankyrin repeat domain-containing protein 36B

Also known as: AN36B_HUMAN, FLJ21281, KIAA1641

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N2N9
Gene: ANKRD36B
Ensembl: ENSG00000196912
Chromosome: 2
Canonical length: 1353 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1353 residues, UniProt reviewed canonical sequence.

>Q8N2N9|ANKRD36B
     1  MERLCSDGFA FPHYYIKPYH LKRIHRAVLR GNLEKLKYLL LTYYDANKRD RKERTALHLA
    61  CATGQPEMVH LLVSRRCELN LCDREDRTPL IKAVQLRQEA CATLLLQNGA DPNITDVFGR
   121  TALHYAVYNE DTSMIEKLLS HGTNIEECSK NEYQPLLLAV SRRKVKMVEF LLKKKANVNA
   181  IDYLGRSALI LAVTLGEKDI VILLLQHNID VFSRDVYGKL AEDYASEAEN RVIFDLIYEY
   241  KRKRYEDLPI NSNPVSPQKQ RAEKATSDDK DSVSNIATEI KEGPISGTVS SQKQPAEKAT
   301  SDEKDSVSNI ATEIKEGQQS GTVSPQKQSA QKVIFKKKVS LLNIATRIMG GGKSGTVSSQ
   361  KQPASKTASD KTDSALNTAT EIKDGLQCGT VSSQKQQALK ATTDEEGSVS NIATEIKDGE
   421  KSGTVSSQKK PALKATSDEK DSFSNITREK KDGEISRTVS SQKPPALKAT SVKEDSVLNI
   481  AREKKDGEKS RTVSFEQPPG LKATRDEKDS LLNIARGKKD GEKTRRVSSH KQPSLKATSD
   541  KEDSVPNMAT ETKDEQISGT VSCQKQPALK ATSDKKDSVS NIPTEIKDGQ QSGTVSSQKQ
   601  PAWKATSVKK DSVSNIATEI KDGQIRGTVS SQRRPALKTT GDEKDSVSNI AREIKDGEKS
   661  GTVSPQKQSA QKVIFKKKVS LLNIATRITG GGKSGTEYPE NLRTLKATIE NKDSVLNTAT
   721  KMKEVQTSTP AEQDLEMASE GEQKRLEEYE NNQPQVKNQI HSRDDLDDII QSSQTVSEDG
   781  DSLCCNCKNV ILLIDQHEMK CKDCVHLLKI KNTFCLWKRL IKLKDNHCEQ LRVKIRKLKN
   841  KASVLQKRIS EKEEIKSQLK HEILELEKEL CSLRFAIQQE KKKRRNVEEL HQKVREKLRI
   901  TEEQYRIEAD VTKPIKPALK SAEVELKTGG NNSNQVSETD EKEDLLHENR LMQDEIARLR
   961  LEKDTIKNQN LEKKYLKDFE IVKRKHEDLQ KALKRNGETL AKTIACYSGQ LAALTDENTT
  1021  LRSKLEKQRE SRQRLETEMQ SYRCRLNAAR CDHDQSHSSK RDQELAFQGT VDKCRHLQEN
  1081  LNSHVLILSL QLSKAESKSR VLKTELHYTG EALKEKALVF EHVQSELKQK QSQMKDIEKM
  1141  YKSGYNTMEK CIEKQERFCQ LKKQNMLLQQ QLDDARNKAD NQEKAILNIQ ARCDARVQNL
  1201  QAECRKHRLL LEEDNKMLVN ELNHSKEKEC QYEKEKAERE VAVRQLQQKR DDVLNKGSAT
  1261  KALLDASSRH CTYLENGMQD SRKKLDQMRS QFQEIQDQLT ATIRCTKEME GDTQKLEVEH
  1321  VMMRKIIKKQ DDQIERLEKI LQHSSLMLQV FES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD36B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 7.1 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 7.1 nTPM
testis: 4.4 nTPM
ovary: 3.4 nTPM
cerebellum: 3.3 nTPM
salivary gland: 2.9 nTPM
fallopian tube: 2.8 nTPM

Single-cell type

sertoli cells: 198 nCPM
thyrotrophs: 129 nCPM
lactotrophs: 115 nCPM
somatotrophs: 103 nCPM
early spermatids: 93 nCPM
retinal ganglion cells: 89 nCPM

Immune cell

basophil: 2.1 nTPM
naive CD4 T-cell: 1 nTPM
naive B-cell: 0.9 nTPM
memory CD4 T-cell: 0.8 nTPM
NK-cell: 0.8 nTPM
plasmacytoid DC: 0.8 nTPM

Brain region

cerebellum: 26 nTPM
white matter: 19 nTPM
thalamus: 18 nTPM
pons: 17 nTPM
cerebral cortex: 17 nTPM
amygdala: 15 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

identical protein binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD36B as an antibody target. Whether an autoantibody or antibody against ANKRD36B could matter depends on whether native ANKRD36B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD36B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD36B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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