Seroatlas · Human Serome Atlas

ANKRD36

Ankyrin repeat domain-containing protein 36A

Also known as: AN36A_HUMAN, UNQ2430

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6QL64
Gene: ANKRD36
Ensembl: ENSG00000135976
Chromosome: 2
Canonical length: 1915 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable ion channel inhibitor activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1915 residues, UniProt reviewed canonical sequence.

>A6QL64|ANKRD36
     1  MEDGKRERWP TLMERLCSDG FAFPQYPIKP YHLKRIHRAV LHGNLEKLKY LLLTYYDANK
    61  RDRKERTALH LACATGQPEM VHLLVSRRCE LNLCDREDRT PLIKAVQLRQ EACATLLLQN
   121  GANPNITDFF GRTALHYAVY NEDTSMIEKL LSHGTNIEEC SKCEYQPLLF AVSRRKVKMV
   181  EFLLKKKANV NAIDYLGRSA LIHAVTLGEK DIVILLLQHN IDVLSRDAFR KIAGDYAIEA
   241  KNRVIFDLIY EYERKRYEDL PINSNPVSSQ KQPALKATSG KEDSISNIAT EIKDGQKSGT
   301  VSSQKQPALK DTSDKDDSVS NTATEIKDEQ KSGTVLPAVE QCLNRSLYRP DAVAQPVTEN
   361  EFSLESEIIS KLYIPKRKII SPRSIKDVLP PVEEAVDRCL YLLDRFAQPV TKDKFALESE
   421  NISEPYFTNR RTISQQSAEN LDAACGIDKT ENGNMFEDQN VDKEGKALPA TGQKANVSPE
   481  QPPLFTHTVK DRDHISTRFL GGMDSLTSSE ESSERPPLST LTLKEADPSS KAAMRRKDSP
   541  PPGKVSSQKQ PAEKATSDDK DSVSNIATEI KEGPISGTVS SQKQPAEKAT SDEKDSVSNI
   601  ATEIKKGQQS GTVSPQKQSA WKVIFKKKVS LLNIATRIMG GGKSGTVSSQ KQPASKATSD
   661  KTDSALNIAT EIKDGLQCGT VSSQKQPALK ATTDEEDSVS NIATEIKDGE KSGTVSSQKQ
   721  PALKATTDEE DSVSNIATEI KDGEKSGTVS SQKQPALKAT TDEKDSVSNI ATEIKDGEKS
   781  GTVSSQKPPA LTATSDEEGS VLSIARENKD GEKSRTVSSR KKPALKATSD EKDSFSNITR
   841  GKKDGEISRK VSSQKPPTLK GTSDEEDSVL GIARENKDGE KSRTVSSEKP PGLKASSAEK
   901  DSVLNIARGK KDGEKTKRVS SRKKPSLEAT SDEKDSFSNI TREKKDGEIS RKVSSQKPPA
   961  LKGTSDEEDS VLGIARENKD GEKSRTVSSE KPPGLKATSD EKDSVLNIAR GKKDGEKTRT
  1021  VSSQKPPTLK ATSDEEDSVL SIARENKDGE KSRTVSSEKP SGLKATSAEK DSVLNIARGK
  1081  KYGEKTKRVS SRKKPALKAT SDEKDSVLYI AREKKDGEKS RTVSSPKQPA LKAICDKEDS
  1141  VPNMATEKKD EQISGTVSCQ KQPALKATSD KKDSVSNIPT EIKDGQQSGT VSSQKQPAWK
  1201  ATSVKKDSVS NIATEIKDGQ IRGTVSPQKQ SAQKVIFKKK VSLLNIATRI TGGWKSGTEY
  1261  PENLPTLKAT IENKNSVLNT ATKMKDVQTS TPAEQDLEMA SEGEQKRLEE YENNQPQVKN
  1321  QIHSRDDLDD IIQSSQTVSE DGDSLCCNCK NVILLIDQHE MKCKDCVHLL KIKNTFCLWK
  1381  RLIKLKDNHC EQLRVKIRKL KNKASVLQKR ISEKEEIKSQ LKHEILELEK ELCSLRFAIQ
  1441  QEKKKRRNVE EVHQKVREKL RITEEQYRIE ADVTKPIKPA LKSAEVELKT GGNNSNQVSE
  1501  TDEKEDLLHE NRLMQDEIAR LRLEKDTIKN QNLEKKYLKD FEIVKRKHED LQKALKRNGE
  1561  TLAKTIACYS GQLAALTDEN TTLRSKLEKQ RESRQRLETE MQSYHCRLNA ARCDHDQSHS
  1621  SKRDQELAFQ GTVDKCRHLQ ENLNSHVLIL SLQLSKAESK SRVLKTELHY TGEALKEKAL
  1681  VFEHVQSELK QKQSQMKDIE KMYKSGYNTM EKCIEKQERF CQLKKQNMLL QQQLDDARNK
  1741  ADNQEKAILN IQARCDARVQ NLQAECRKHR LLLEEDNKML VNELNHSKEK ECQYEKEKAE
  1801  REVAVRQLQQ KRDDVLNKGS ATKALLDASS RHCTYLENGM QDSRKKLDQM RSQFQEIQDQ
  1861  LTATIRCTKE MEGDTQKLEV EHVMMRKIIK KQDDQIERLE KILQHSSLML QVFES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

retina: 18 nTPM
bone marrow: 10 nTPM
testis: 6.6 nTPM
cerebellum: 5.5 nTPM
epididymis: 3.8 nTPM
endometrium: 3.2 nTPM

Single-cell type

brain inhibitory neurons: 394 nCPM
brain excitatory neurons: 355 nCPM
oligodendrocytes: 258 nCPM
other brain neurons: 240 nCPM
lactotrophs: 222 nCPM
oligodendrocyte progenitor cells: 212 nCPM

Immune cell

plasmacytoid DC: 6.3 nTPM
naive B-cell: 4.9 nTPM
gdT-cell: 4.7 nTPM
MAIT T-cell: 4.7 nTPM
naive CD8 T-cell: 4.7 nTPM
memory B-cell: 4.6 nTPM

Brain region

cerebellum: 74 nTPM
pons: 46 nTPM
basal ganglia: 46 nTPM
white matter: 45 nTPM
cerebral cortex: 44 nTPM
thalamus: 41 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ANKRD36.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 76 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: -1.38
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD36 as an antibody target. Whether an autoantibody or antibody against ANKRD36 could matter depends on whether native ANKRD36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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