Seroatlas · Human Serome Atlas

ANKRD34C

Ankyrin repeat domain-containing protein 34C

Also known as: AN34C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C6C1
Gene: ANKRD34C
Ensembl: ENSG00000235711
Chromosome: 15
Canonical length: 535 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be active in pi-body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

535 residues, UniProt reviewed canonical sequence.

>P0C6C1|ANKRD34C
     1  MMDDDTELRT DGNSLLKAVW LGRLRLTRLL LEGGAYINES NDKGETALMV ACITKHVDQQ
    61  SISKSKMVKY LLDNRADPNI QDKSGKTALI HACIRRAGGE VVSLLLENGA DPSLEDRTGA
   121  SALVYAINAD DKDALKHLLD ACKAKGKEVI IITTDKSSSG TKTTKQYLNV PPSPKVEDRH
   181  SPPLCASPSD IELKALGLDS PLTEKEDDFF SLQAGHPSSC NTSKAVNEPG SPTRKVSNLK
   241  RARLPQLKRL QSEPWGLIAP SVLAASTRQD ETHGASTDNE VIKSISDISF PKRGPLSRTN
   301  SIDSKDPTLF HTVTEQVLKI PVSSAPASWK AAYEKGQAPH PRLARRGTLP VDQEKCGMGP
   361  SGPSALKEPA SLKWLENDLY DLDIQPGPDP PNSISLESGK GPLDRKKLNS SHLSLFHGSR
   421  ESLDTVPSTS PSSARRRPPH LLERRGSGTL LLDRISHTRP GFLPPLNVNL NPPIPDIRSS
   481  SKPSCSLASG LKSMVPVAPS SPKRVDLRSK KKLLRRHSMQ IEQMKQLSDF EEIMT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD34C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 2.6 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 2.6 nTPM
hypothalamus: 2 nTPM
cerebral cortex: 1.5 nTPM
midbrain: 0.9 nTPM
blood vessel: 0.6 nTPM
pituitary gland: 0.6 nTPM

Single-cell type

thyrotrophs: 8.7 nCPM
oocytes: 4.6 nCPM
other brain neurons: 2.8 nCPM
lactotrophs: 2.6 nCPM
brain excitatory neurons: 2.4 nCPM
somatotrophs: 2.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 13 nTPM
pons: 9.4 nTPM
hypothalamus: 8.5 nTPM
midbrain: 7.6 nTPM
cerebral cortex: 6.9 nTPM
cerebellum: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.21
gnomAD missense Z: 2.14
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

pi-body

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD34C as an antibody target. Whether an autoantibody or antibody against ANKRD34C could matter depends on whether native ANKRD34C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD34C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD34C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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