Seroatlas · Human Serome Atlas

ANKRD34B

Ankyrin repeat domain-containing protein 34B

Also known as: AN34B_HUMAN, DP58

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A5PLL1
Gene: ANKRD34B
Ensembl: ENSG00000189127
Chromosome: 5
Canonical length: 514 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

Predicted to be located in cytoplasm and nucleus. Predicted to be active in pi-body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

514 residues, UniProt reviewed canonical sequence.

>A5PLL1|ANKRD34B
     1  MDEGMEISSE GNSLIKAVHQ SRLRLTRLLL EGGAYINESN DRGETPLMIA CKTKHVDHQS
    61  VSKAKMVKYL LENNADPNIQ DKSGKTALMH ACLEKAGPEV VSLLLKSGAD LSLQDHSSYS
   121  ALVYAINSED TETLKVLLSA CKAKGKEVII ITTAKLPCGK HTTKQYLNMP PVDIDGCHSP
   181  ATCTTPSEID IKTASSPLSH SSETELTLFG FKDLELAGSN DDTWDPGSPV RKPALAPKGP
   241  KLPHAPPWVK SPPLLMHQNR VASLQEELQD ITPEEELSYK TNGLALSKRF ITRHQSIDVK
   301  DTAHLLRAFD QASSRKMSYD EINCQSYLSE GNQQCIEVPV DQDPDSNQTI FASTLRSIVQ
   361  KRNLGANHYS SDSQLSAGLT PPTSEDGKAL IGKKKILSPS PSQLSESKEL LENIPPGPLS
   421  RRNHAVLERR GSGAFPLDHS VTQTRQGFLP PLNVNSHPPI SDINVNNKIC SLLSCGQKVL
   481  MPTVPIFPKE FKSKKMLLRR QSLQTEQIKQ LVNF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD34B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 11 nTPM
hypothalamus: 3.1 nTPM
bone marrow: 1.6 nTPM
tonsil: 1.2 nTPM
lymph node: 0.8 nTPM
midbrain: 0.8 nTPM

Single-cell type

neutrophils: 81 nCPM
brain inhibitory neurons: 41 nCPM
neutrophil progenitors: 15 nCPM
renal connecting tubule cells: 11 nCPM
other brain neurons: 8 nCPM
monocytes: 5.2 nCPM

Immune cell

neutrophil: 3.8 nTPM
classical monocyte: 0.7 nTPM
intermediate monocyte: 0.2 nTPM
eosinophil: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM

Brain region

hypothalamus: 83 nTPM
basal ganglia: 33 nTPM
medulla oblongata: 8.9 nTPM
cerebellum: 7.8 nTPM
amygdala: 6.5 nTPM
thalamus: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD34B as an antibody target. Whether an autoantibody or antibody against ANKRD34B could matter depends on whether native ANKRD34B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD34B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD34B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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