Seroatlas · Human Serome Atlas

ANKRD34A

Ankyrin repeat domain-containing protein 34A

Also known as: AN34A_HUMAN, ANKRD34

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q69YU3
Gene: ANKRD34A
Ensembl: ENSG00000272031
Chromosome: 1
Canonical length: 496 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to be active in pi-body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>Q69YU3|ANKRD34A
     1  MLHTEGHALL RAVGQGKLRL ARLLLEGGAY VNEGDAQGET ALMAACRARY DDPQNKARMV
    61  RYLLEQGADP NIADRLGRTA LMHACAGGGG AAVASLLLAH GADPSVRDHA GASALVHALD
   121  RGDRETLATL LDACKAKGTE VIIITTDTSP SGTKKTRQYL NSPPSPGVED PAPASPSPGF
   181  CTSPSEIQLQ TAGGGGRGML SPRAQEEEEK RDVFEFPLPK PPDDPSPSEP LPKPPRHPPK
   241  PLKRLNSEPW GLVAPPQPVP PTEGRPGIER LTAEFNGLTL TGRPRLSRRH STEGPEDPPP
   301  WAEKVTSGGP LSRRNTAPEA QESGPPSGLR QKLSRMEPVE LDTPGHLCPD SPESSRLSLE
   361  RRRYSASPLT LPPAGSAPSP RQSQESLPGA VSPLSGRRRS PGLLERRGSG TLLLDHISQT
   421  RPGFLPPLNV SPHPPIPDIR PQPGGRAPSL PAPPYAGAPG SPRTKRKLVR RHSMQTEQIR
   481  LLGGFQSLGG PGEPGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD34A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 18 nTPM
cerebral cortex: 17 nTPM
basal ganglia: 9.5 nTPM
hippocampal formation: 8.8 nTPM
amygdala: 8.1 nTPM
hypothalamus: 7 nTPM

Single-cell type

retinal bipolar cells: 7.3 nCPM
brain excitatory neurons: 7 nCPM
cardiomyocytes: 6.8 nCPM
brain inhibitory neurons: 5.5 nCPM
other brain neurons: 5.1 nCPM
paneth cells: 3.9 nCPM

Immune cell

gdT-cell: 1.1 nTPM
naive CD8 T-cell: 1.1 nTPM
MAIT T-cell: 0.8 nTPM
naive CD4 T-cell: 0.7 nTPM
memory CD8 T-cell: 0.6 nTPM
naive B-cell: 0.6 nTPM

Brain region

cerebral cortex: 44 nTPM
basal ganglia: 25 nTPM
white matter: 24 nTPM
cerebellum: 24 nTPM
hippocampal formation: 23 nTPM
amygdala: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 0.98
gnomAD missense Z: 2.46
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

pi-body

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD34A as an antibody target. Whether an autoantibody or antibody against ANKRD34A could matter depends on whether native ANKRD34A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD34A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD34A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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