Seroatlas · Human Serome Atlas

ANKRD33B

Ankyrin repeat domain-containing protein 33B

Also known as: AN33B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NCL7
Gene: ANKRD33B
Ensembl: ENSG00000164236
Chromosome: 5
Canonical length: 494 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

No narrative summary is available for ANKRD33B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

494 residues, UniProt reviewed canonical sequence.

>A6NCL7|ANKRD33B
     1  MVLLAGTGPE GGGARCMTPP PPSPPRGAQV EEDPADYEEF EDFSSLPDTR SIASDDSFYP
    61  FEDEEEHGVE SAESVPEGVP ESVPETATLL RAACANNVGL LRTLVRRGVS VEEAQETDRN
   121  GRTGLIVACY HGFVDTVVAL AECPHVDVNW QDSEGNTALI TAAQAGHAII TNYLLNYFPG
   181  LDLERRNAFG FTALMKAAMQ GRTDCIRALM LAGADVHARD PRRGMSPQEW ATYTGRVDAV
   241  RLMQRLLERP CPEQFWEKYR PELPPPPEAA RKPAGSKNCL QRLTDCVLSV LTPRSVRGPE
   301  DGGVLDHMVR MTTSLYSPAV AIVCQTVCPE SPPSVGKRRL AVQEILAARA ARGPQAQEED
   361  EVGGAGQRGR TGQEDADSRE GSPRAGLPPA LGSRGPAAPA PRKASLLPLQ RLRRRSVRPG
   421  VVVPRVRVSK APAPTFQPER PARKGSTKDS GHLQIPKWRY KEAKEEKRKA EEAEKKRQAE
   481  AQKERRTAPW KKRT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD33B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

retina: 47 nTPM
bone marrow: 8.6 nTPM
tongue: 7.9 nTPM
cerebral cortex: 7 nTPM
spleen: 6.8 nTPM
skin: 6.6 nTPM

Single-cell type

cone photoreceptor cells: 1,166 nCPM
podocytes: 658 nCPM
rod photoreceptor cells: 380 nCPM
endometrial luminal cells: 351 nCPM
platelets: 242 nCPM
neutrophil progenitors: 201 nCPM

Immune cell

eosinophil: 0.3 nTPM
memory B-cell: 0.2 nTPM
naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hippocampal formation: 58 nTPM
cerebral cortex: 41 nTPM
basal ganglia: 27 nTPM
amygdala: 24 nTPM
white matter: 22 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.55
gnomAD pLI: 0.43
gnomAD missense Z: 2.09
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD33B as an antibody target. Whether an autoantibody or antibody against ANKRD33B could matter depends on whether native ANKRD33B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD33B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD33B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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