Seroatlas · Human Serome Atlas

ANKRD33

Photoreceptor ankyrin repeat protein

Also known as: C12orf7, DKFZp686O1689, PANKY, PANKY_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z3H0
Gene: ANKRD33
Ensembl: ENSG00000167612
Chromosome: 12
Canonical length: 452 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to act upstream of or within skeletal muscle cell differentiation. Predicted to be located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

452 residues, UniProt reviewed canonical sequence.

>Q7Z3H0|ANKRD33
     1  MKVQPSVTCV ASWGGIVHLE AFGDPVIVLR GAWAVPRVDC LIDTLRTPNA SCMRKGTHLL
    61  VPCLEEEELA LHRRRLDMSE ALPCPGKETP TPGCRLGALY WACVHNDPTQ LQAILDGGVS
   121  PEEATQVDSN GRTGLMVACY HGFQSVVALL SHCPFLDVNQ QDKGGDTALM LAAQAGHVPL
   181  VSLLLNYYVG LDLERRDQRG LTALMKAAMR NRCADLTAVD PVRGKTALEW AVLTDSFDTV
   241  WRIRQLLRRP QVEQLSQHYK PEWPALSGLV AQAQAQAQVA PSLLERLQAT LSLPFAPSPQ
   301  EGGVLDHLVT ATTSLASPFV TTACHTLCPD HPPSLGTRSK SVPELLGTAP PPPLVPQSPP
   361  GSPQRSPWVF VPYQSPQGIL SKCLQWLQPR DSTSPRPQVP KILLSKASSS SHQCQPKPSP
   421  SGHQSLALPL WRYQELRIEK RKQEEEARMA QK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

retina: 17 nTPM
parathyroid gland: 2 nTPM
placenta: 0.5 nTPM
liver: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

rod photoreceptor cells: 90 nCPM
cone photoreceptor cells: 68 nCPM
syncytiotrophoblasts: 10 nCPM
retinal horizontal cells: 6 nCPM
retinal pigment epithelial cells: 4.3 nCPM
retinal bipolar cells: 2.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.8 nTPM
pons: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: 0.34
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

skeletal muscle cell differentiation

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD33 as an antibody target. Whether an autoantibody or antibody against ANKRD33 could matter depends on whether native ANKRD33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD33 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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