Seroatlas · Human Serome Atlas

ANKRD30BL

Putative ankyrin repeat domain-containing protein 30B-like

Also known as: A30BL_HUMAN, ANKRD30BP3, NCRNA00164

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A7E2S9
Gene
ANKRD30BL
Ensembl
ENSG00000163046
Chromosome
2
Canonical length
258 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

No narrative summary is available for ANKRD30BL in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

258 residues, UniProt reviewed canonical sequence.

>A7E2S9|ANKRD30BL
     1  MERLSAAPVK GQTGPERPSP FSQLVYTNND SYVIHHGDLR KIHKAASRGQ AWKLERMMKK
    61  TTMDLNIRDA KKRTALYWAC ANGHAEVVTL LVDRKCQLDV LDGENRTILM KALQCQREAC
   121  ANILIDSGAD PNIVDVYGNT AVHYAVNSEN LSVVAKLLSC GADIEVKNKA GHTPLLLAIR
   181  KRSEEIVEFL LTKNANANAV DKFKCVHQQL LEYKQKISKN SQNSNPEGTS EGTPDEAAPL
   241  AERTPDTAES LVERTPDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD30BL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
7.4 nTPM

Expression across tissuesHPA

Tissue

  • testis: 7.4 nTPM
  • basal ganglia: 0.2 nTPM
  • fallopian tube: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM
  • hypothalamus: 0.2 nTPM
  • amygdala: 0.1 nTPM

Single-cell type

  • choroid plexus epithelial cells: 526 nCPM
  • brain inhibitory neurons: 418 nCPM
  • other brain neurons: 379 nCPM
  • brain excitatory neurons: 314 nCPM
  • ependymal cells: 159 nCPM
  • retinal amacrine cells: 158 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD30BL as an antibody target. Whether an autoantibody or antibody against ANKRD30BL could matter depends on whether native ANKRD30BL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD30BL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD30BL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANKRD30BL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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