Seroatlas · Human Serome Atlas

ANKRD30B

Ankyrin repeat domain-containing protein 30B

Also known as: AN30B_HUMAN, NY-BR-1.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BXX2
Gene
ANKRD30B
Ensembl
ENSG00000180777
Chromosome
18
Canonical length
1392 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

No narrative summary is available for ANKRD30B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1392 residues, UniProt reviewed canonical sequence.

>Q9BXX2|ANKRD30B
     1  MKRLLAAAGK GVRGPEPPNP FSERVYTEKD YGTIYFGDLG KIHTAASRGQ VQKLEKMTVG
    61  KKPVNLNKRD MKKRTALHWA CVNGHAEVVT FLVDRKCQLN VLDGEGRTPL MKALQCEREA
   121  CANILIDAGA DLNYVDVYGN TALHYAVYSE NLLMVATLLS YGAVIEVQNK ASLTPLLLAI
   181  QKRSKQTVEF LLTKNANANA FNESKCTALM LAICEGSSEI VGMLLQQNVD VFAEDIHGIT
   241  AERYAAACGV NYIHQQLLEH IRKLPKNPQN TNPEGTSTGT PDEAAPLAER TPDTAESLLE
   301  KTPDEAARLV EGTSAKIQCL GKATSGKFEQ STEETPRKIL RPTKETSEKF SWPAKERSRK
   361  ITWEEKETSV KTECVAGVTP NKTEVLEKGT SNMIACPTKE TSTKASTNVD VSSVEPIFSL
   421  FGTRTIENSQ CTKVEEDFNL ATKIISKSAA QNYTCLPDAT YQKDIKTINH KIEDQMFPSE
   481  SKREEDEEYS WDSGSLFESS AKTQVCIPES MYQKVMEINR EVEELPEKPS AFKPAVEMQK
   541  TVPNKAFELK NEQTLRAAQM FPSESKQKDD EENSWDSESP CETVSQKDVY LPKATHQKEF
   601  DTLSGKLEES PVKDGLLKPT CGRKVSLPNK ALELKDRETF KAESPDKDGL LKPTCGRKVS
   661  LPNKALELKD RETLKAESPD NDGLLKPTCG RKVSLPNKAL ELKDRETFKA AQMFPSESKQ
   721  KDDEENSWDF ESFLETLLQN DVCLPKATHQ KEFDTLSGKL EESPDKDGLL KPTCGMKISL
   781  PNKALELKDR ETFKAEDVSS VESTFSLFGK PTTENSQSTK VEEDFNLTTK EGATKTVTGQ
   841  QERDIGIIER APQDQTNKMP TSELGRKEDT KSTSDSEIIS VSDTQNYECL PEATYQKEIK
   901  TTNGKIEESP EKPSHFEPAT EMQNSVPNKG LEWKNKQTLR ADSTTLSKIL DALPSCERGR
   961  ELKKDNCEQI TAKMEQTKNK FCVLQKELSE AKEIKSQLEN QKAKWEQELC SVRLTLNQEE
  1021  EKRRNVDILK EKIRPEEQLR KKLEVKQQLE QTLRIQDIEL KSVTSNLNQV SHTHESENDL
  1081  FHENCMLKKE IAMLKLEVAT LKHQHQVKEN KYFEDIKILQ EKNAELQMTL KLKQKTVTKR
  1141  ASQYREQLKV LTAENTMLTS KLKEKQDKEI LETEIESHHP RLASALQDHD QSVTSRKNQE
  1201  LAFHSAGDAP LQGIMNVDVS NTIYNNEVLH QPLYEAQRKS KSPKINLNYA GDDLRENALV
  1261  SEHAQRDRCE TQCQMKKAEH MYQNEQDNVD KHTEQQESLE QKLFQLESKN RWLRQQLVYA
  1321  HKKVNKSKVT INIQFPEMKM QRHLNEKNEE VFNYGNHLKE RIDQYEKEKA EREVSIKKYK
  1381  YFSNFLKESG LG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD30B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
8.3 nTPM

Expression across tissuesHPA

Tissue

  • testis: 8.3 nTPM
  • breast: 1.3 nTPM
  • basal ganglia: 0.6 nTPM
  • cerebral cortex: 0.6 nTPM
  • bone marrow: 0.5 nTPM
  • hypothalamus: 0.3 nTPM

Single-cell type

  • early primary spermatocytes: 79 nCPM
  • brain inhibitory neurons: 50 nCPM
  • other brain neurons: 38 nCPM
  • brain excitatory neurons: 36 nCPM
  • late primary spermatocytes: 30 nCPM
  • mesothelial cells: 17 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 2.3 nTPM
  • white matter: 2.2 nTPM
  • hypothalamus: 2 nTPM
  • medulla oblongata: 2 nTPM
  • basal ganglia: 1.8 nTPM
  • midbrain: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
-0.72
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD30B as an antibody target. Whether an autoantibody or antibody against ANKRD30B could matter depends on whether native ANKRD30B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD30B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD30B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANKRD30B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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