Seroatlas · Human Serome Atlas

ANKRD30A

Ankyrin repeat domain-containing protein 30A

Also known as: AN30A_HUMAN, NY-BR-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXX3
Gene: ANKRD30A
Ensembl: ENSG00000148513
Chromosome: 10
Canonical length: 1397 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

This gene encodes a DNA-binding transcription factor that is uniquely expressed in mammary epithelium and the testis. Altered expression levels have been associated with breast cancer progression. [provided by RefSeq, Nov 2016]

Canonical amino-acid sequenceUniProt

1397 residues, UniProt reviewed canonical sequence.

>Q9BXX3|ANKRD30A
     1  MEEISAAAVK VVPGPERPSP FSQLVYTSND SYIVHSGDLR KIHKAASRGQ VRKLEKMTKR
    61  KKTINLNIQD AQKRTALHWA CVNGHEEVVT FLVDRKCQLD VLDGEHRTPL MKALQCHQEA
   121  CANILIDSGA DINLVDVYGN TALHYAVYSE ILSVVAKLLS HGAVIEVHNK ASLTPLLLSI
   181  TKRSEQIVEF LLIKNANANA VNKYKCTALM LAVCHGSSEI VGMLLQQNVD VFAADICGVT
   241  AEHYAVTCGF HHIHEQIMEY IRKLSKNHQN TNPEGTSAGT PDEAAPLAER TPDTAESLVE
   301  KTPDEAAPLV ERTPDTAESL VEKTPDEAAS LVEGTSDKIQ CLEKATSGKF EQSAEETPRE
   361  ITSPAKETSE KFTWPAKGRP RKIAWEKKED TPREIMSPAK ETSEKFTWAA KGRPRKIAWE
   421  KKETPVKTGC VARVTSNKTK VLEKGRSKMI ACPTKESSTK ASANDQRFPS ESKQEEDEEY
   481  SCDSRSLFES SAKIQVCIPE SIYQKVMEIN REVEEPPKKP SAFKPAIEMQ NSVPNKAFEL
   541  KNEQTLRADP MFPPESKQKD YEENSWDSES LCETVSQKDV CLPKATHQKE IDKINGKLEE
   601  SPNKDGLLKA TCGMKVSIPT KALELKDMQT FKAEPPGKPS AFEPATEMQK SVPNKALELK
   661  NEQTLRADEI LPSESKQKDY EENSWDTESL CETVSQKDVC LPKAAHQKEI DKINGKLEGS
   721  PVKDGLLKAN CGMKVSIPTK ALELMDMQTF KAEPPEKPSA FEPAIEMQKS VPNKALELKN
   781  EQTLRADEIL PSESKQKDYE ESSWDSESLC ETVSQKDVCL PKATHQKEID KINGKLEESP
   841  DNDGFLKAPC RMKVSIPTKA LELMDMQTFK AEPPEKPSAF EPAIEMQKSV PNKALELKNE
   901  QTLRADQMFP SESKQKKVEE NSWDSESLRE TVSQKDVCVP KATHQKEMDK ISGKLEDSTS
   961  LSKILDTVHS CERARELQKD HCEQRTGKME QMKKKFCVLK KKLSEAKEIK SQLENQKVKW
  1021  EQELCSVRLT LNQEEEKRRN ADILNEKIRE ELGRIEEQHR KELEVKQQLE QALRIQDIEL
  1081  KSVESNLNQV SHTHENENYL LHENCMLKKE IAMLKLEIAT LKHQYQEKEN KYFEDIKILK
  1141  EKNAELQMTL KLKEESLTKR ASQYSGQLKV LIAENTMLTS KLKEKQDKEI LEAEIESHHP
  1201  RLASAVQDHD QIVTSRKSQE PAFHIAGDAC LQRKMNVDVS STIYNNEVLH QPLSEAQRKS
  1261  KSLKINLNYA GDALRENTLV SEHAQRDQRE TQCQMKEAEH MYQNEQDNVN KHTEQQESLD
  1321  QKLFQLQSKN MWLQQQLVHA HKKADNKSKI TIDIHFLERK MQHHLLKEKN EEIFNYNNHL
  1381  KNRIYQYEKE KAETENS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD30A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

breast: 62 nTPM
testis: 1.7 nTPM
adipose tissue: 1.6 nTPM
placenta: 0.1 nTPM
skin: 0.1 nTPM
adrenal gland: 0 nTPM

Single-cell type

breast hormone-responsive cells: 828 nCPM
early primary spermatocytes: 102 nCPM
adipocytes: 49 nCPM
breast myoepithelial cells: 47 nCPM
early spermatids: 42 nCPM
renal collecting duct intercalated cells: 36 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.6 nTPM
cerebral cortex: 0.3 nTPM
medulla oblongata: 0.2 nTPM
midbrain: 0.2 nTPM
white matter: 0.2 nTPM
amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0
gnomAD missense Z: -2.83
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD30A as an antibody target. Whether an autoantibody or antibody against ANKRD30A could matter depends on whether native ANKRD30A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD30A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD30A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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