Seroatlas · Human Serome Atlas

ANKRD26P1

Putative ankyrin repeat domain-containing protein 26-like protein

Also known as: AR26L_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NSI1
Gene: ANKRD26P1
Canonical length: 321 aa

OverviewNCBI Gene

No narrative summary is available for ANKRD26P1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>Q6NSI1|ANKRD26P1
     1  MRRSSGFGGQ KGQGPSCSFT GCWCCRGDDV AESDDSPFAQ CGYNIQEKHL GKLHRAASRG
    61  EVSKVECILS SGSADLDERD KKKRTALHLA CANGHPEVVA LLVDRGCQLD VFDNKNRTAL
   121  LKAVQCQEEE CATILLEHGA DPDLPDVYGN TTLHYAIYNE DIPMTKKLLL HHANIESANK
   181  DELTPFLLAV HEQKQQMEDF LRKQKENLTA VKLESIHQVM SEYKENETPR NPQNSNPEGT
   241  SNKMACLGEG AAGAKVDEIP GNPVKRLFNK PSIDDSRPMS ANEDFDFDTE EKATEPANGK
   301  RQNGMGIIES APQEHTNNEN I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD26P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD26P1 as an antibody target. Whether an autoantibody or antibody against ANKRD26P1 could matter depends on whether native ANKRD26P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD26P1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD26P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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