Seroatlas · Human Serome Atlas

ANKRD22

Ankyrin repeat domain-containing protein 22

Also known as: ANR22_HUMAN, MGC22805

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5VYY1
Gene
ANKRD22
Ensembl
ENSG00000152766
Chromosome
10
Canonical length
191 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for ANKRD22 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

191 residues, UniProt reviewed canonical sequence.

>Q5VYY1|ANKRD22
     1  MGILYSEPIC QAAYQNDFGQ VWRWVKEDSS YANVQDGFNG DTPLICACRR GHVRIVSFLL
    61  RRNANVNLKN QKERTCLHYA VKKKFTFIDY LLIILLMPVL LIGYFLMVSK TKQNEALVRM
   121  LLDAGVEVNA TDCYGCTALH YACEMKNQSL IPLLLEARAD PTIKNKHGES SLDIARRLKF
   181  SQIELMLRKA L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 28 nTPM
  • skin: 24 nTPM
  • esophagus: 18 nTPM
  • appendix: 9 nTPM
  • pancreas: 8.1 nTPM
  • vagina: 7.9 nTPM

Single-cell type

  • esophageal apical cells: 297 nCPM
  • mucous neck cells: 234 nCPM
  • suprabasal keratinocytes: 197 nCPM
  • gastric chief cells: 193 nCPM
  • esophageal suprabasal cells: 172 nCPM
  • parietal cells: 172 nCPM

Immune cell

  • neutrophil: 6.4 nTPM
  • intermediate monocyte: 3.1 nTPM
  • classical monocyte: 2.1 nTPM
  • eosinophil: 1.1 nTPM
  • non-classical monocyte: 0.6 nTPM
  • total PBMC: 0.6 nTPM

Brain region

  • medulla oblongata: 2.8 nTPM
  • pons: 2 nTPM
  • white matter: 1.9 nTPM
  • cerebral cortex: 1.5 nTPM
  • hypothalamus: 1.5 nTPM
  • midbrain: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.72
gnomAD pLI
0
gnomAD missense Z
-0.21
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD22 as an antibody target. Whether an autoantibody or antibody against ANKRD22 could matter depends on whether native ANKRD22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANKRD22. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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