Seroatlas · Human Serome Atlas

ANKRD20A8P

Ankyrin repeat domain-containing protein 20B

Also known as: AN20B_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5CZ79
Gene: ANKRD20A8P
Canonical length: 823 aa

OverviewNCBI Gene

No narrative summary is available for ANKRD20A8P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

823 residues, UniProt reviewed canonical sequence.

>Q5CZ79|ANKRD20A8P
     1  MKLFGFGSRR GQTAEGSIDH VYTGSGYRIR DSELQKIHRA AVKGDAAEVE RCLARRSGDL
    61  DARDKQHRTA LHLACASGHV QVVTLLVNRK CQIDICDKEN RTPLIQAVHC QEEACAVILL
   121  KHGANPNLKD IYGNTALHYA VYSESTSLAE KLLSHGAHIE ALDKDSNTPL LFAIICKKEK
   181  MVEFLLKKKA STHAVDRLRR SALMLAVYYD SPGIVSILLK QNIDVFAQDM CGRDAEDYAI
   241  SHHLTKIQQQ ILEHKQKILK KEKSDVGSSD ESAVSIFHEL RVDSLPASDD KDLSVATKQC
   301  VPEKVSEPLP GPSHEKGNRI VNGQGEGPPA KHPSLKPTTG VEDPAVKGAV QRKNVQTLRA
   361  EQALPVASEE EQERHERSEK KQPQVKKGNN TNKSEKIQLS ENICDSTSSA AAGRLTQQRK
   421  IGKTYPQQFP KKLKEEHDKC TLKQENEEKT NVNMLYKKNR EELERKEKQY KKEVEAKQLE
   481  PTVQSLEMKS KTARNTPNRD FHNHEETKGL MDENCILKAD IAILRQEICT MKNDNLEKEN
   541  KYLKDIKIVK ETNAALEKYI KLNEEMITET AFRYQQELND LKAENTRLNA ELLKEKESKK
   601  RLEADIESYQ SRLAAAIGKH SESVKTERNV KLALERTQDV SVQVEMSSAI SKVKDENEFL
   661  TEQLSETQIK FNALKDKFRK TRDSLRKKSL ALETVQNDLR KTQQQTQEMK EMYQNAEAKV
   721  NNSTGKWNCV EERICHLQRE NAWLVQQLDD VHQKEDHKEI VTNIQRGFIE SGKKDLVLEE
   781  KSKKLMNECD HLKESLFQYE REKAEGVVSI KEDKYFQTSR KKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD20A8P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD20A8P as an antibody target. Whether an autoantibody or antibody against ANKRD20A8P could matter depends on whether native ANKRD20A8P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD20A8P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD20A8P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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