Seroatlas · Human Serome Atlas

ANKRD20A4P

Putative ankyrin repeat domain-containing protein 20A4

Also known as: A20A4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4UJ75
Gene: ANKRD20A4P
Canonical length: 823 aa

OverviewNCBI Gene

No narrative summary is available for ANKRD20A4P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

823 residues, UniProt reviewed canonical sequence.

>Q4UJ75|ANKRD20A4P
     1  MKLFGFGSRR GQTAQGSIDH VYTGSGYRIR DSELQKIHRA AVKGDAAEVE RCLARRSGEL
    61  DALDKQHRTA LHLACASGHV QVVTLLVNRK CQIDVCDKEN RTPLIQAVHC QEEACAVILL
   121  EHGANPNLKD IYGNTALHYA VYSESTSLAE KLLSHGAHIE ALDKDNNTPL LFAIICKKEK
   181  MVEFLLKKKA SSHAVDRLRR SALMLAVYYD SPGIVNILLK QNIDVFAQDM CGRDAEDYAI
   241  SHHLTKIQQQ ILEHKKKILK KEKSDVGSSD ESAVSIFHEL RVDSLPASDD KDLNVATKQC
   301  VPEKVSEPLP GSSHEKGNRI VNGQGEGPPA KHPSLKPSTE VEDPAVKGAV QRKNVQTLRA
   361  EQALPVASEE EQQRHERSEK KQPQVKEGNN TNKSEKIQLS ENICDSTSSA AAGRLTQQRK
   421  IGKTYPQQFP KKLKEEHDRC TLKQENEEKT NVNMLYKKNR EELERKEKQY KKEVEAKQLE
   481  PTVQSLEMKS KTARNTPNWD FHNHEEMKGL MDENCILKAD IAILRQEICT MKNDNLEKEN
   541  KYLKDIKIVK ETNAALEKYI KLNEEMITET AFRYQQELND LKAENTRLNA ELLKEKESKK
   601  RLEADIESYQ SRLAAAISKH SESVKTERNL KLALERTQDV SVQVEMSSAI SKVKDENEFL
   661  TEQLSETQIK FNALKDKFRK TRDSLRKKSL ALETVQNNLS QTQQQTQEMK EMYQNAEAKV
   721  NNSTGKWNCV EERICHLQRE NAWLVQQLDD VHQKEDHKEI VTNIQRGFIE SGKKDFVLEE
   781  KSKKLMNECD HLKESLFQYE REKTEVVVSI KEDKYFQTSR KKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD20A4P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD20A4P as an antibody target. Whether an autoantibody or antibody against ANKRD20A4P could matter depends on whether native ANKRD20A4P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD20A4P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD20A4P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...