Seroatlas · Human Serome Atlas

ANKRD20A1

Ankyrin repeat domain-containing protein 20A1

Also known as: A20A1_HUMAN, ANKRD20A, DKFZp434A171

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TYW2
Gene: ANKRD20A1
Ensembl: ENSG00000260691
Chromosome: 9
Canonical length: 823 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

823 residues, UniProt reviewed canonical sequence.

>Q5TYW2|ANKRD20A1
     1  MKLFGFGSRR GQTAQGSIDH VYTGSGYRIR DSELQKIHRA AVKGDAAEVE RCLARRSGDL
    61  DALDKQHRTA LHLACTSGHV QVVTLLVNRK CQIDVCDKEN RTPLIQAVHC QEEACAVILL
   121  EHGANPNLKD IYGNTALHYA VYSESTSLAE KLLSHGAHIE ALDKDNNTPL LFAIICKKEK
   181  MVEFLLKKKA SSHAVDRLRR SALMLAVYYD SPGIVNILLK QNIDVFAQDM CGRDAEDYAI
   241  SHHLTKIQQQ ILEHKKKILK KEKSDVGSSD ESAVSIFHEL RVDSLPASDD KDLNVATKQC
   301  VPEKVSEPLP GSSHEKGNRI VNGQGEGPPA KHPSLKPSTE VEDPAVKGAV QRKNVQTLRA
   361  EQALPVASEE EQERHERSEK KQPQVKEGNN TNKSEKIQLS ENICDSTSSA AAGRLTQQRK
   421  IGKTYPQQFP KKLKEEHDRC TLKQENEEKT NVNMLYKKNR EELERKEKQY KKEVEAKQLE
   481  PTVQSLEMKS KTARNTPNWD FHNHEEMKGL MDENCILKAD IAILRQEICT MKNDNLEKEN
   541  KYLKDIKIVK ETNAALEKYI KLNEEMITET AFRYQQELND LKAENTRLNA ELLKEKESKK
   601  RLEADIESYQ SRLAAAISKH SESVKTERNL KLALERTRDV SVQVEMSSAI SKVKAENEFL
   661  TEQLSETQIK FNALKDKFRK TRDSLRKKSL ALETVQNDLS QTQQQTQEMK EMYQNAEAKV
   721  NNSTGKWNCV EERICHLQRE NAWLVQQLDD VHQKEDHKEI VTNIQRGFIE SGKKDLVLEE
   781  KSKKLMNECD HLKESLFQYE REKTEGVVSI KEDKYFQTSR KTI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD20A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

testis: 3.9 nTPM
heart muscle: 1.1 nTPM
pancreas: 1.1 nTPM
spleen: 1 nTPM
placenta: 0.9 nTPM
adipose tissue: 0.7 nTPM

Single-cell type

undifferentiated spermatogonia: 62 nCPM
early primary spermatocytes: 25 nCPM
differentiating spermatogonia: 14 nCPM
oligodendrocyte progenitor cells: 12 nCPM
late primary spermatocytes: 7.3 nCPM
epididymal efferent duct absorptive cells: 6.9 nCPM

Immune cell

plasmacytoid DC: 0.2 nTPM
eosinophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

basal ganglia: 15 nTPM
hypothalamus: 15 nTPM
cerebral cortex: 15 nTPM
hippocampal formation: 13 nTPM
pons: 13 nTPM
white matter: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: -0.13

OntologyGO

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD20A1 as an antibody target. Whether an autoantibody or antibody against ANKRD20A1 could matter depends on whether native ANKRD20A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD20A1 is annotated at the cell surface, where native ANKRD20A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ANKRD20A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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