Seroatlas · Human Serome Atlas

ANKRD18B

Ankyrin repeat domain-containing protein 18B

Also known as: AN18B_HUMAN, bA255A11.3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A2A2Z9
Gene: ANKRD18B
Ensembl: ENSG00000230453
Chromosome: 9
Canonical length: 1011 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ANKRD18B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1011 residues, UniProt reviewed canonical sequence.

>A2A2Z9|ANKRD18B
     1  MRKLLSFGRR LGQALLSSMD QEYAGRGYHI RDWELRKIHR AAIKGDAAEV EHCLTRRFRD
    61  LDVRDRKDRT VLHLACAHGR VQVVTLLLDR KCQINICDRL NRTPLMKAVH CQEEACAIIL
   121  LKRGANPNIK DIYGNTALHY AVYNEGTSLA ERLLSHHANI EALNKEGNTP LLFAINSRRQ
   181  HMVEFLLKNQ ANIHAVDNFK RTALILAVQH NLSSIVTLLL QQNIHISSQD MFGQTAEDYA
   241  FCCDLRSIQQ QILEHKNKML KNHLRNDNQE TAAMKPENLK KRKKRKKLKK RKEGAKAEHN
   301  LKVASEEKQE RLERSENKQP QDSQSYGKKK DEMFGNFMLK RDIAMLKEEL YAIKNDSLRK
   361  EKKYIQEIKS ITEINANFEK SVRLNEEMIT KKVAQYSQQL NDLKAENARL NSKLEKEKHN
   421  KERLEAEVES LHSNLATAIN EYNEILERKD LELVLWRADD VSRHETMGSN ISQLTDKNEL
   481  LTEQVHKARV KFNTLKGKLR ETRDALREKT LALESVQLDL KQAQHRIKEM KQMHPNGEAK
   541  ESQSIGKQNS SEERIRQREL ENLLLERQLE DARKEGDNKE IVINIHRDCL ENGKEDLLEE
   601  RNKELMNEYN YLKEKLLQYE KEKAEREVIV REFQEELVDH LKKFSMSESP LEGTSHCHIN
   661  LDETWTSKKK LFQVEIQPEE KHEEFRKVFE LISLLNYTAD QIRKKNRELE EEATGYKKCL
   721  EMTINMLNAF ANEDFSCHGD LNTDQLKMDI LFKKLKQKFD DLMAEKEAVS SKCVNLAKDN
   781  EVLHQELLSM GKVQEKCEKL EKDKKMLEEK VLNLKTHMEK DMVELGKVQE YKSELDERAM
   841  QAIEKLEEIH LQKQAEYEKQ LEQLNKDNTA SLKKKELTLK DVECKFSKMK TAYEDVTTEL
   901  EEYKEAFAVA LKANSSMSEK ITKSDKKIAV ISTKLFMEKE RMEYFLSTLP MRPDPELPCV
   961  ENLNSIELNR KYIPKMAIRI PTSNPQTSNN CKNSLTELLL RWALAPIYFL L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD18B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 7.7 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 7.7 nTPM
testis: 4.1 nTPM
amygdala: 3.2 nTPM
skin: 3 nTPM
cerebral cortex: 2.9 nTPM
retina: 2.8 nTPM

Single-cell type

sertoli cells: 131 nCPM
epididymal efferent duct ciliated cells: 82 nCPM
early spermatids: 60 nCPM
müller glia: 38 nCPM
brain excitatory neurons: 28 nCPM
retinal pigment epithelial cells: 26 nCPM

Immune cell

basophil: 0.3 nTPM
naive B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 56 nTPM
pons: 43 nTPM
cerebral cortex: 32 nTPM
medulla oblongata: 29 nTPM
midbrain: 24 nTPM
basal ganglia: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0
gnomAD missense Z: 0.47

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD18B as an antibody target. Whether an autoantibody or antibody against ANKRD18B could matter depends on whether native ANKRD18B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD18B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD18B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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