Seroatlas · Human Serome Atlas

ANKRD18A

Ankyrin repeat domain-containing protein 18A

Also known as: AN18A_HUMAN, FLJ35740, KIAA2015

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IVF6
Gene
ANKRD18A
Ensembl
ENSG00000180071
Chromosome
9
Canonical length
992 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for ANKRD18A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

992 residues, UniProt reviewed canonical sequence.

>Q8IVF6|ANKRD18A
     1  MRKLFSFGRR LGQALLSSMD QEYAGPGYDI RDWELRKIHR AAIKGDAAEV ERCLTRRFRD
    61  LDARDRKDRT VLHLACAHGR VQVVTLLLHR RCQIDICDRL NRTPLMKAVH SQEEACAIVL
   121  LECGANPNIE DIYGNTALHY AVYNKGTSLA ERLLSHHANI EALNKEGNTP LLFAINSRRQ
   181  HMVEFLLKNQ ANIHAVDNFK RTALILAVQH NLSSIVTLLL QQNIRISSQD MFGQTAEDYA
   241  LCSDLRSIRQ QILEHKNKML KNHLRNDNQE TAAMKPANLK KRKERAKAEH NLKVASEEKQ
   301  ERLQRSENKQ PQDSQSYGKK KDAMYGNFML KKDIAMLKEE LYAIKNDSLR KEKKYIQEIK
   361  SITEINANFE KSVRLNEKMI TKTVARYSQQ LNDLKAENAR LNSELEKEKH NKERLEAEVE
   421  SLHSSLATAI NEYNEIVERK DLELVLWRAD DVSRHEKMGS NISQLTDKNE LLTEQVHKAR
   481  VKFNTLKGKL RETRDALREK TLALGSVQLD LRQAQHRIKE MKQMHPNGEA KESQSIGKQN
   541  SLEERIRQQE LENLLLERQL EDARKEGDNK EIVINIHRDC LENGKEDLLE ERNKELMKEY
   601  NYLKEKLLQC EKEKAEREVI VREFQEELVD HLKTFSISES PLEGTSHCHI NLNETWTSKK
   661  KLFQVEIQPE EKHEEFRKLF ELISLLNYTA DQIRKKNREL EEEATGYKKC LEMTINMLNA
   721  FANEDFSCHG DLNTDQLKMD ILFKKLKQKF NDLVAEKEAV SSECVNLAKD NEVLHQELLS
   781  MRNVQEKCEK LEKDKKMLEE EVLNLKTHME KDMVELGKLQ EYKSELDERA VQEIEKLEEI
   841  HLQKQAEYEK QLEQLNKDNT ASLKKKELTL KDVECKFSKM KTAYEEVTTE LEEFKEAFAG
   901  AVKANNSMSK KLMKSDKKIA VISTKLFTEK QRMKYFLSTL PTRPEPELPC VENLNSIELN
   961  RKYIPKTAIR IPTSNPQTSN NCKNFLTEVL LC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD18A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 18 nTPM
  • testis: 7.2 nTPM
  • spinal cord: 4.7 nTPM
  • retina: 4 nTPM
  • thyroid gland: 2.2 nTPM
  • pancreas: 2.1 nTPM

Single-cell type

  • sertoli cells: 475 nCPM
  • neutrophil progenitors: 212 nCPM
  • gonadotrophs: 132 nCPM
  • epididymal efferent duct ciliated cells: 110 nCPM
  • rod photoreceptor cells: 96 nCPM
  • endometrial ciliated cells: 91 nCPM

Immune cell

  • naive CD8 T-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM

Brain region

  • white matter: 45 nTPM
  • medulla oblongata: 33 nTPM
  • pons: 30 nTPM
  • basal ganglia: 22 nTPM
  • thalamus: 21 nTPM
  • midbrain: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
0.68
DepMap mean gene effect
0.04
DepMap dependency class
selective

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD18A as an antibody target. Whether an autoantibody or antibody against ANKRD18A could matter depends on whether native ANKRD18A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD18A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD18A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANKRD18A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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