Seroatlas · Human Serome Atlas

ANKRD16

Ankyrin repeat domain-containing protein 16

Also known as: ANR16_HUMAN, DKFZP434N1511

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P6B7
Gene: ANKRD16
Ensembl: ENSG00000134461
Chromosome: 10
Canonical length: 361 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Predicted to be involved in tRNA modification. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>Q6P6B7|ANKRD16
     1  MAQPGDPRRL CRLVQEGRLR ALKEELQAAG GCPGPAGDTL LHCAARHGHR DVLAYLAEAW
    61  GMDIEATNRD YKRPLHEAAS MGHRDCVRYL LGRGAAVDCL KKADWTPLMM ACTRKNLGVI
   121  QELVEHGANP LLKNKDGWNS FHIASREGDP LILQYLLTVC PGAWKTESKI RRTPLHTAAM
   181  HGHLEAVKVL LKRCQYEPDY RDNCGVTALM DAIQCGHIDV ARLLLDEHGA CLSAEDSLGA
   241  QALHRAAVTG QDEAIRFLVS ELGVDVDVRA TSTHLTALHY AAKEGHTSTI QTLLSLGADI
   301  NSKDEKNRSA LHLACAGQHL ACAKFLLQSG LKDSEDITGT LAQQLPRRAD VLQGSGHSAM
   361  T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 8.3 nTPM

Expression across tissuesHPA

Tissue

testis: 8.3 nTPM
skin: 6.3 nTPM
stomach: 6.3 nTPM
cervix: 6.1 nTPM
ovary: 5.9 nTPM
fallopian tube: 5.6 nTPM

Single-cell type

myonuclei: 60 nCPM
retinal horizontal cells: 56 nCPM
brain inhibitory neurons: 39 nCPM
choroid plexus epithelial cells: 34 nCPM
ependymal cells: 31 nCPM
retinal amacrine cells: 31 nCPM

Immune cell

plasmacytoid DC: 0.5 nTPM
naive B-cell: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM
NK-cell: 0.4 nTPM
memory B-cell: 0.3 nTPM
basophil: 0.2 nTPM

Brain region

cerebral cortex: 20 nTPM
basal ganglia: 15 nTPM
white matter: 15 nTPM
cerebellum: 15 nTPM
pons: 15 nTPM
amygdala: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0
gnomAD missense Z: 0.04
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

tRNA modification

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANKRD16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

AARS
AARS1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD16 as an antibody target. Whether an autoantibody or antibody against ANKRD16 could matter depends on whether native ANKRD16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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